生殖因素与子宫肌瘤风险

Reproductive factors and risk of uterine fibroids.

作者信息

Parazzini F, Negri E, La Vecchia C, Chatenoud L, Ricci E, Guarnerio P

机构信息

Istituto di Ricerche Farmacologiche, Mario Negri, Milan, Italy.

出版信息

Epidemiology. 1996 Jul;7(4):440-2. doi: 10.1097/00001648-199607000-00018.

DOI:10.1097/00001648-199607000-00018

PMID:8793374

Abstract

We analyzed the relation between reproductive history and risk of uterine fibroids using data from a case-control study. Cases were 621 women with histologically confirmed diagnosis of uterine fibroids. Controls were 1,051 non-hysterectomized patients. Compared with nulliparae, parous women had a relative risk (RR) of fibroids of 0.5 [95% confidence interval (CI) = 0.4-0.6], and the risk declined with number of births. The risk of fibroids also decreased with number of induced abortions (RR = 0.8 and 0.6 for women reporting one or two or more abortions, respectively). A total of 24 cases (3.9%) and 19 controls (1.8%) reported a history of infertility (RR = 2.0; 95% CI = 1.1-3.7).

摘要

我们利用一项病例对照研究的数据，分析了生殖史与子宫肌瘤风险之间的关系。病例为621名经组织学确诊为子宫肌瘤的女性。对照为1051名未接受子宫切除术的患者。与未生育女性相比，经产妇患子宫肌瘤的相对风险（RR）为0.5 [95%置信区间（CI）= 0.4 - 0.6]，且风险随分娩次数的增加而降低。子宫肌瘤的风险也随人工流产次数的增加而降低（分别报告一次、两次或更多次流产的女性的RR = 0.8和0.6）。共有24例（3.9%）病例和19名对照（1.8%）报告有不孕史（RR = 2.0；95% CI = 1.1 - 3.7）。