Parazzini F, Negri E, La Vecchia C, Rabaiotti M, Luchini L, Villa A, Fedele L
Istituto di Ricerche, Farmacologiche, Mario Negri, Milan, Italy.
J Reprod Med. 1996 May;41(5):316-20.
To evaluate the relationship between smoking and uterine myomas requiring surgery.
We conducted a case-control study in Milan between 1986 and 1992. Cases were 476 patients under 55 years of age with histologically confirmed myomas. Controls were 1,283 women admitted to the hospital for a spectrum of acute, other-than-gynecologic, hormonal or neoplastic conditions (30% trauma, 25% nontraumatic orthopedic conditions, 25% surgical, 20% other miscellaneous).
Cases were less frequently current smokers (22%) than controls (32%). In comparison with never smokers, the multivariate relative risk (RR) for myomas was 0.5 (95% confidence interval [CI], 0.4-0.7) in smokers. Ex-smokers were 10% of cases versus 7% of controls (RR 1.2, 95% CI 0.9-1.8). No clear trend in risk was observed with the number of cigarettes smoked per day or duration of smoking and risk of fibroids. The estimated RRs were largely consistent when separate analyses were performed in strata of age and other selected covariates, including indices of body weight.
Current smoking seems to reduce the risk of myomas.
评估吸烟与需手术治疗的子宫肌瘤之间的关系。
1986年至1992年期间，我们在米兰进行了一项病例对照研究。病例为476例55岁以下经组织学确诊为子宫肌瘤的患者。对照为1283名因一系列急性、非妇科、激素或肿瘤性疾病入院的女性（30%为创伤，25%为非创伤性骨科疾病，25%为手术，20%为其他杂项）。
病例组当前吸烟者的比例（22%）低于对照组（32%）。与从不吸烟者相比，吸烟者患子宫肌瘤的多因素相对风险（RR）为0.5（95%置信区间[CI]，0.4 - 0.7）。既往吸烟者在病例组中占10%，在对照组中占7%（RR 1.2，95% CI 0.9 - 1.8）。未观察到每日吸烟量或吸烟持续时间与患肌瘤风险之间存在明显的风险趋势。在按年龄和其他选定协变量（包括体重指数）分层进行单独分析时，估计的RR在很大程度上是一致的。
当前吸烟似乎可降低患子宫肌瘤的风险。
