Muñoz-Criado S, Muñoz-Bellido J L, García-Rodríguez J A
Department of Microbiology, Hospital Clínico Universitario, Salamanca, Spain.
Eur J Clin Microbiol Infect Dis. 1996 May;15(5):418-20. doi: 10.1007/BF01690103.
The in vitro antimicrobial activity of streptomycin, rifampicin, tetracycline, seven nonsteroidal anti-inflammatory agents (acetyl-salicylic acid, piroxicam, indomethacin, ibuprofen, ketoprofen, sulindac, and diclofenac), and eight phenotiazine derivatives and antidepressant agents (clorpromazine, fluphenazine, amitryptiline, clomipramine, imipramine, maprotiline, sertraline, and diazepam) against 62 strains of Brucella spp. was tested. Diclofenac was the most active of the anti-inflammatory agents (MIC90 = 16 micrograms/ml). The activity of the phenotiazines and antidepressants was heterogeneous, with MIC90s ranging from 16 micrograms/ml for sertraline and 32 micrograms/ml for fluphenazine and clomipramine to > 512 micrograms/ml for diazepam. When the six most active anti-inflammatory agents and the six most active psychiatric drugs were tested at pH 5 and pH 4, the MICs remained unchanged except for those of fluphenazine; the MIC50 and MIC90 of this agent increased by one dilution.
测试了链霉素、利福平、四环素、七种非甾体抗炎药（乙酰水杨酸、吡罗昔康、吲哚美辛、布洛芬、酮洛芬、舒林酸和双氯芬酸）以及八种吩噻嗪衍生物和抗抑郁药（氯丙嗪、氟奋乃静、阿米替林、氯米帕明、丙咪嗪、马普替林、舍曲林和地西泮）对62株布鲁氏菌属菌株的体外抗菌活性。双氯芬酸是抗炎药中活性最强的（MIC90 = 16微克/毫升）。吩噻嗪类药物和抗抑郁药的活性各不相同，MIC90范围从舍曲林的16微克/毫升、氟奋乃静和氯米帕明的32微克/毫升到地西泮的>512微克/毫升。当在pH 5和pH 4条件下测试六种活性最强的抗炎药和六种活性最强的精神药物时，除氟奋乃静外，MIC保持不变；该药物的MIC50和MIC90增加了一个稀释度。
