Coutaux A F, Mooney J J, Wirth D F
Department of Tropical Public Health, Harvard School of Public Health, Boston, Massachusetts 02115.
Antimicrob Agents Chemother. 1994 Jun;38(6):1419-21. doi: 10.1128/AAC.38.6.1419.
Chloroquine resistance in Plasmodium falciparum was reversed in vitro by the neuronal monoamine reuptake inhibitors and antidepressants desipramine, sertraline, fluoxetine, and norfluoxetine but not by carbamazepine, an antiseizure and mood-stabilizing tricyclic drug resembling desipramine which only weakly inhibits neuronal monoamine reuptake. These findings have important clinical implications for drug combination therapy.
恶性疟原虫对氯喹的耐药性在体外可被神经元单胺再摄取抑制剂及抗抑郁药地昔帕明、舍曲林、氟西汀和去甲氟西汀逆转，但不能被卡马西平逆转，卡马西平是一种抗癫痫和稳定情绪的三环类药物，与地昔帕明相似，仅能微弱抑制神经元单胺再摄取。这些发现对联合药物治疗具有重要的临床意义。
