神经元单胺再摄取抑制剂增强了抗氯喹恶性疟原虫在体外对氯喹的敏感性。
Neuronal monoamine reuptake inhibitors enhance in vitro susceptibility to chloroquine in resistant Plasmodium falciparum.
作者信息
Coutaux A F, Mooney J J, Wirth D F
机构信息
Department of Tropical Public Health, Harvard School of Public Health, Boston, Massachusetts 02115.
出版信息
Antimicrob Agents Chemother. 1994 Jun;38(6):1419-21. doi: 10.1128/AAC.38.6.1419.
Abstract
Chloroquine resistance in Plasmodium falciparum was reversed in vitro by the neuronal monoamine reuptake inhibitors and antidepressants desipramine, sertraline, fluoxetine, and norfluoxetine but not by carbamazepine, an antiseizure and mood-stabilizing tricyclic drug resembling desipramine which only weakly inhibits neuronal monoamine reuptake. These findings have important clinical implications for drug combination therapy.
摘要
恶性疟原虫对氯喹的耐药性在体外可被神经元单胺再摄取抑制剂及抗抑郁药地昔帕明、舍曲林、氟西汀和去甲氟西汀逆转，但不能被卡马西平逆转，卡马西平是一种抗癫痫和稳定情绪的三环类药物，与地昔帕明相似，仅能微弱抑制神经元单胺再摄取。这些发现对联合药物治疗具有重要的临床意义。
相似文献
1
Neuronal monoamine reuptake inhibitors enhance in vitro susceptibility to chloroquine in resistant Plasmodium falciparum.神经元单胺再摄取抑制剂增强了抗氯喹恶性疟原虫在体外对氯喹的敏感性。
Antimicrob Agents Chemother. 1994 Jun;38(6):1419-21. doi: 10.1128/AAC.38.6.1419.
2
Role of the neurotransmitter reuptake-blocking activity of antidepressants in reversing chloroquine resistance in vitro in Plasmodium falciparum.抗抑郁药的神经递质再摄取阻断活性在体外逆转恶性疟原虫氯喹抗性中的作用。
Antimicrob Agents Chemother. 2000 Oct;44(10):2689-92. doi: 10.1128/AAC.44.10.2689-2692.2000.
3
Reversal of chloroquine resistance with desipramine in isolates of Plasmodium falciparum from Central and West Africa.在来自中非和西非的恶性疟原虫分离株中，用去甲丙咪嗪逆转氯喹抗性。
Trans R Soc Trop Med Hyg. 1990 Jul-Aug;84(4):479-81. doi: 10.1016/0035-9203(90)90006-z.
4
Desipramine reversal of chloroquine resistance in wild isolates of Plasmodium falciparum.去甲丙咪嗪逆转恶性疟原虫野生分离株对氯喹的耐药性。
Lancet. 1990 Jan 20;335(8682):164-5. doi: 10.1016/0140-6736(90)90034-3.
5
Pharmacokinetics of desipramine coadministered with sertraline or fluoxetine.与舍曲林或氟西汀合用时去甲丙咪嗪的药代动力学。
J Clin Psychopharmacol. 1994 Apr;14(2):90-8.
6
Reversal of chloroquine resistance in malaria parasite Plasmodium falciparum by desipramine.地昔帕明逆转恶性疟原虫对氯喹的耐药性。
Science. 1988 Dec 2;242(4883):1301-3. doi: 10.1126/science.3057629.
7
Enhancement of drug susceptibility in Plasmodium falciparum in vitro and Plasmodium berghei in vivo by mixed-function oxidase inhibitors.混合功能氧化酶抑制剂增强恶性疟原虫体外及伯氏疟原虫体内的药物敏感性
Antimicrob Agents Chemother. 1993 Jun;37(6):1318-23. doi: 10.1128/AAC.37.6.1318.
8
Fluoxetine hydrochloride enhances in vitro susceptibility to chloroquine in resistant Plasmodium falciparum.盐酸氟西汀增强耐药恶性疟原虫对氯喹的体外敏感性。
Antimicrob Agents Chemother. 1992 Dec;36(12):2761-5. doi: 10.1128/AAC.36.12.2761.
9
Is reversal of chloroquine resistance ready for the clinic?氯喹抗性的逆转已准备好应用于临床了吗？
Lancet. 2001 Mar 24;357(9260):904. doi: 10.1016/s0140-6736(00)04232-x.
10
Reversal of chloroquine resistance of 'wild' isolates of Plasmodium falciparum by desipramine.地昔帕明逆转恶性疟原虫“野生”分离株的氯喹抗性
Trans R Soc Trop Med Hyg. 1991 Nov-Dec;85(6):723-4. doi: 10.1016/0035-9203(91)90427-z.
引用本文的文献
1
Defeating cancer with antidepressants.用抗抑郁药战胜癌症。
Ecancermedicalscience. 2008;2:88. doi: 10.3332/ecancer.2008.88. Epub 2008 Aug 21.
2
Effects of psychological stress and fluoxetine on development of oral candidiasis in rats.心理应激和氟西汀对大鼠口腔念珠菌病发展的影响。
Clin Vaccine Immunol. 2010 Apr;17(4):668-73. doi: 10.1128/CVI.00380-09. Epub 2010 Feb 3.
3
5HT1A serotonin receptor agonists inhibit Plasmodium falciparum by blocking a membrane channel.5-羟色胺1A受体激动剂通过阻断膜通道来抑制恶性疟原虫。
Antimicrob Agents Chemother. 2003 Dec;47(12):3806-9. doi: 10.1128/AAC.47.12.3806-3809.2003.
4
Role of the neurotransmitter reuptake-blocking activity of antidepressants in reversing chloroquine resistance in vitro in Plasmodium falciparum.抗抑郁药的神经递质再摄取阻断活性在体外逆转恶性疟原虫氯喹抗性中的作用。
Antimicrob Agents Chemother. 2000 Oct;44(10):2689-92. doi: 10.1128/AAC.44.10.2689-2692.2000.
5
In vitro activity of nonsteroidal anti-inflammatory agents, phenotiazines, and antidepressants against Brucella species.非甾体抗炎药、吩噻嗪类药物及抗抑郁药对布鲁氏菌属的体外活性。
Eur J Clin Microbiol Infect Dis. 1996 May;15(5):418-20. doi: 10.1007/BF01690103.
本文引用的文献
1
SOLUBILITY OF ACETYLENE IN LUNG TISSUE AS AN ERROR IN CARDIAC OUTPUT DETERMINATION WITH THE ACETYLENE METHOD.
Acta Physiol Scand. 1963 Sep-Oct;59:1-6. doi: 10.1111/j.1748-1716.1963.tb02717.x.
2
Desipramine plasma concentration and antidepressant response.
Arch Gen Psychiatry. 1982 Dec;39(12):1419-22. doi: 10.1001/archpsyc.1982.04290120049010.
3
Reversal of chloroquine resistance in malaria parasite Plasmodium falciparum by desipramine.地昔帕明逆转恶性疟原虫对氯喹的耐药性。
Science. 1988 Dec 2;242(4883):1301-3. doi: 10.1126/science.3057629.
4
Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum.抗药恶性疟原虫中与哺乳动物多药耐药基因相关的一个基因的扩增
Science. 1989 Jun 9;244(4909):1184-6. doi: 10.1126/science.2658061.
5
Desipramine and cyproheptadine for reversal of chloroquine resistance in Plasmodium falciparum.去甲丙咪嗪和赛庚啶用于逆转恶性疟原虫对氯喹的耐药性。
Lancet. 1989 Nov 25;2(8674):1282-3. doi: 10.1016/s0140-6736(89)91895-3.
6
The biochemistry of P-glycoprotein-mediated multidrug resistance.P-糖蛋白介导的多药耐药的生物化学
Annu Rev Biochem. 1989;58:137-71. doi: 10.1146/annurev.bi.58.070189.001033.
7
Antihistaminic drugs that reverse chloroquine resistance in Plasmodium falciparum.可逆转恶性疟原虫对氯喹耐药性的抗组胺药物。
Lancet. 1989 Aug 5;2(8658):334-5. doi: 10.1016/s0140-6736(89)90522-9.
8
Reversal of chloroquine resistance with desipramine in isolates of Plasmodium falciparum from Central and West Africa.在来自中非和西非的恶性疟原虫分离株中，用去甲丙咪嗪逆转氯喹抗性。
Trans R Soc Trop Med Hyg. 1990 Jul-Aug;84(4):479-81. doi: 10.1016/0035-9203(90)90006-z.
9
Desipramine or cyproheptadine for reversing chloroquine resistance?用去甲丙咪嗪或赛庚啶逆转氯喹耐药性？
Lancet. 1990 Feb 17;335(8686):422. doi: 10.1016/0140-6736(90)90265-7.
10
Desipramine reversal of chloroquine resistance in wild isolates of Plasmodium falciparum.去甲丙咪嗪逆转恶性疟原虫野生分离株对氯喹的耐药性。
Lancet. 1990 Jan 20;335(8682):164-5. doi: 10.1016/0140-6736(90)90034-3.
Zotero 插件