Harty J T, Lenz L L, Bevan M J
Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA.
Curr Opin Immunol. 1996 Aug;8(4):526-30. doi: 10.1016/s0952-7915(96)80041-0.
Recent studies have revealed the complexity of cytokine and cellular interactions required for resistance to primary Listeria monocytogenes infection and have illustrated that resistance to secondary infection may occur through multiple pathways. Analyses of Listeria epitope generation and the specificity of protective CD8(+) T cells have suggested that future research should focus on secreted protein antigens in specific resistance to infection and have increased our understanding of Listeria antigens presented by MHC class l-b molecules.
最近的研究揭示了抵抗单核细胞增生李斯特菌原发性感染所需的细胞因子和细胞相互作用的复杂性,并表明对继发性感染的抵抗可能通过多种途径发生。对李斯特菌表位产生和保护性CD8(+) T细胞特异性的分析表明,未来的研究应聚焦于对感染特异性抵抗中的分泌蛋白抗原,这增进了我们对MHC I类分子呈递的李斯特菌抗原的理解。