Mirsky R, Jessen K R
Department of Anatomy and Developmental Biology, University College London, UK.
Curr Opin Neurobiol. 1996 Feb;6(1):89-96. doi: 10.1016/s0959-4388(96)80013-4.
Neu-differentiation factor (glial growth factor) has been established as an important regulator of early Schwann cell development, and the lineage relationship between immature Schwann cells and the neural crest has been clarified by the identification of the Schwann cell precursor. Progress has been made in identifying transcription factors that control Schwann cell development and in defining molecules that positively and negatively regulate myelin differentiation pathways. The tetraspan group has emerged as a set of proteins with prominent functions in Schwann cell biology.
神经分化因子（神经胶质生长因子）已被确认为早期施万细胞发育的重要调节因子，并且通过施万细胞前体的鉴定，已阐明了未成熟施万细胞与神经嵴之间的谱系关系。在识别控制施万细胞发育的转录因子以及确定正向和负向调节髓鞘分化途径的分子方面已取得进展。四跨膜蛋白家族已成为一组在施万细胞生物学中具有突出功能的蛋白质。
