Fraser A, McCarthy N, Evan G I
Imperial Cancer Research Fund Laboratories, London, UK.
Curr Opin Neurobiol. 1996 Feb;6(1):71-80. doi: 10.1016/s0959-4388(96)80011-0.
Apoptosis is a common feature of the nervous system, occurring physiologically during development and pathologically in several diseases. In view of the latter, pathways that regulate apoptosis in neurones are of particular interest, and recent advances in this field implicate several signalling pathways in the induction of apoptosis, after withdrawal of nerve growth factor. Recent information drawn from both mammalian and invertebrate models enables us to assign components of the apoptotic pathway as either regulators or effectors.
细胞凋亡是神经系统的一个常见特征，在发育过程中生理性发生，在几种疾病中病理性发生。鉴于后者，调节神经元细胞凋亡的途径特别令人感兴趣，并且该领域的最新进展表明，在神经生长因子撤除后，几种信号通路参与了细胞凋亡的诱导。从哺乳动物和无脊椎动物模型中获得的最新信息使我们能够将细胞凋亡途径的组成部分分为调节因子或效应器。
