Barisić Karmela, Petrik Jozsef, Rumora Lada
Department of Medical Biochemistry and Hematology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.
Acta Pharm. 2003 Sep;53(3):151-64.
Apoptosis is a physiological cell suicide program that is critical for the development and maintenance of healthy tissues. Regulation of programmed cell death allows the organism to control the cell number and the tissue size, and to protect itself from rogue cells that threaten homeostasis. The changed activity of numerous genes influences switching of cells to a self-destruction program. Apoptosis requires co-ordinated action and fine tuning of a set of proteins that are either regulators or executors of the process. Cancer, autoimmune diseases, immunodeficiency disease, reperfusion injury and neurodegenerative disorders are characterised by disregulation of apoptosis. Modulation of the expression and activation of the key molecular components of the apoptotic process has emerged as an attractive therapeutic strategy for many diseases.
细胞凋亡是一种生理性细胞自杀程序，对健康组织的发育和维持至关重要。程序性细胞死亡的调控使机体能够控制细胞数量和组织大小，并保护自身免受威胁体内平衡的异常细胞的侵害。众多基因活性的改变影响细胞向自我毁灭程序的转变。细胞凋亡需要一组蛋白质协调作用并进行微调，这些蛋白质要么是该过程的调节因子，要么是执行者。癌症、自身免疫性疾病、免疫缺陷病、再灌注损伤和神经退行性疾病的特征是细胞凋亡失调。调节凋亡过程关键分子成分的表达和激活已成为许多疾病颇具吸引力的治疗策略。
