Johansson C, Molander U, Milsom I, Ekelund P
Department of Geriatrics, Vasa Hospital, University of Göteborg, Sweden.
Maturitas. 1996 Apr;23(3):265-71. doi: 10.1016/0378-5122(95)00982-5.
The association between urinary disorders, such as ongoing urinary incontinence (UI), history of urinary incontinence (HIST-UI) and urinary tract infections (UTI), and fractures in peri- and postmenopausal women was assessed in an epidemiological study.
The sample consisted of 10000 women from seven birth cohorts, born between 1900 and 1940, who were investigated regarding urinary disorders, fractures and reproductive history by means of a postal questionnaire.
The overall response rate was 74.6%. The respondents (n = 7459) represented 53% of the total population from the respective birth cohorts. There was a significant independent correlation between UI, HIST-UI and UTI, respectively, and fractures after the age of 30. In subjects with HIST-UI, tobacco smokers compared to non-smokers had significant more fractures in both the 1930 and 1940 birth cohorts (P < 0.01). Logistic multiple regression in the 1930 and 1940 cohorts demonstrated that age (P < 0.001), HIST-UI (P < 0.001) and tobacco smoking (P < 0.05), respectively, had an independent explanatory value for fractures.
The prevalence of fractures increased with increasing age, in smokers compared to non-smokers and in women with a history of UI.
在一项流行病学研究中，评估了诸如持续性尿失禁（UI）、尿失禁病史（HIST-UI）和尿路感染（UTI）等泌尿系统疾病与绝经前后女性骨折之间的关联。
样本包括来自七个出生队列的10000名女性，她们出生于1900年至1940年之间，通过邮寄问卷对泌尿系统疾病、骨折和生殖史进行了调查。
总体应答率为74.6%。应答者（n = 7459）占相应出生队列总人口的53%。UI、HIST-UI和UTI分别与30岁以后的骨折之间存在显著的独立相关性。在有HIST-UI的受试者中，1930年和1940年出生队列中，吸烟者与非吸烟者相比，骨折明显更多（P < 0.01）。1930年和1940年队列的逻辑多元回归表明，年龄（P < 0.001）、HIST-UI（P < 0.001）和吸烟（P < 0.05）分别对骨折具有独立的解释价值。
骨折患病率随年龄增长、吸烟者与非吸烟者相比以及有UI病史的女性而增加。
