精神分裂症的复发：与物质滥用有关系吗？

Relapse in schizophrenia: is there a relationship to substance abuse?

作者信息

Gupta S, Hendricks S, Kenkel A M, Bhatia S C, Haffke E A

机构信息

Omaha VA Medical Center, NE 68105, USA.

出版信息

Schizophr Res. 1996 May;20(1-2):153-6. doi: 10.1016/0920-9964(95)00108-5.

DOI:10.1016/0920-9964(95)00108-5

PMID:8794503

Abstract

This retrospective study evaluated relapse in 22 patients with schizophrenia, comparing substance abusers with nonabusers. Medication compliance was ensured as all subjects were treated with decanoate neuroleptics. Substance abuse was documented by multiple urine drug screens. Substance abusers had a significantly higher readmission rate to the hospital compared to nonabusers. These data suggest that in the presence of documented medication compliance substance abuse remains a major factor contributing towards relapse.

摘要

这项回顾性研究评估了22例精神分裂症患者的复发情况，比较了药物滥用者和非药物滥用者。由于所有受试者均接受癸酸神经阻滞剂治疗，因此确保了药物依从性。通过多次尿液药物筛查记录药物滥用情况。与非药物滥用者相比，药物滥用者的再次入院率显著更高。这些数据表明，在有记录的药物依从性情况下，药物滥用仍然是导致复发的一个主要因素。