Kunugi H, Takei N, Murray R M, Saito K, Nanko S
Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan.
Schizophr Res. 1996 May;20(1-2):165-70. doi: 10.1016/0920-9964(96)00007-2.
The growing evidence for neurodevelopmental basis to schizophrenia has focused attention on the prenatal development of individuals who later develop the illness. Several previous studies have shown reduced birth weight (BW) in schizophrenics and one recently reported smaller birth head circumference (BHC). The current study compared 67 DSM-III-R schizophrenics and a general population group of 1640, using information obtained from contemporaneous birth records. When gestational age and gender were controlled for, no significant difference was found in BW between the schizophrenics and the comparison population. However, the preschizophrenics showed significantly smaller BHC for gestational age, suggestive of slower fetal brain growth.
越来越多的证据表明精神分裂症具有神经发育基础，这使得人们将注意力集中在后来患上这种疾病的个体的产前发育上。此前的几项研究表明，精神分裂症患者出生体重（BW）较低，最近有一项研究报告称其出生时头围（BHC）较小。本研究使用从同期出生记录中获取的信息，对67名DSM-III-R精神分裂症患者和1640名普通人群进行了比较。在对孕周和性别进行控制后，精神分裂症患者与对照人群的出生体重没有显著差异。然而，患精神分裂症之前的个体显示出其头围相对于孕周明显较小，这表明胎儿脑部生长较慢。
