Yagoubi N, Denuziere A, Pellerin F, Ferrier D
Centre d'Etudes Pharmaceutiques, Laboratoire de Chimie Analytique III, Chatenay-Malabry.
Ann Pharm Fr. 1996;54(3):126-30.
Multilayer plastic materials provide useful solutions for primary pharmaceutical formulae (maintaining physical properties, compatibility with contents, protection against exterior agents). Fourier transform infrared spectometry is an ideal method to identify and quantify the different polymers and additives. Each functional group has a characteristic band which can be selected and rapidly identified for routine quality control. The proportional quantities of each polymers in the multilayer system can be determined directly using the characteristic bands for each functional group. The technique was applied to the analysis of heat-formed platelets made of polyvinyl chloride and polyvinylidene chloride.
多层塑料材料为主要药物配方提供了有用的解决方案（保持物理性质、与内容物的相容性、抵御外部因素）。傅里叶变换红外光谱法是鉴定和定量不同聚合物及添加剂的理想方法。每个官能团都有一个特征谱带，可用于常规质量控制的选择和快速鉴定。多层体系中各聚合物的比例量可直接使用每个官能团的特征谱带来确定。该技术应用于由聚氯乙烯和聚偏二氯乙烯制成的热成型片材的分析。
