皮炎芽生菌细胞表面分子在宿主-病原体相互作用中的作用。
Role of cell-surface molecules of Blastomyces dermatitidis in host-pathogen interactions.
作者信息
Klein B S, Newman S L
机构信息
Depts of Pediatrics, University of Wisconsin Medical School, Madison, 53792, USA.
出版信息
Trends Microbiol. 1996 Jun;4(6):246-51. doi: 10.1016/0966-842X(96)10028-7.
PMID:8795162
Abstract
The fungal pathogen Blastomyces dermatitidis produces an adhesin (WI-1) in yeast stages, which contains repetitive regions that bind host-cell receptors. Adhesin and glucan may modulate fungal interactions with macrophages; their level of expression is altered in hypovirulent mutants. Adhesin is also involved in immune responses, and may be important in eliciting the clearance of the fungus.
摘要
真菌病原体皮炎芽生菌在酵母阶段产生一种黏附素（WI-1），其含有与宿主细胞受体结合的重复区域。黏附素和葡聚糖可能调节真菌与巨噬细胞的相互作用；它们在低毒力突变体中的表达水平会发生改变。黏附素也参与免疫反应，并且在引发真菌清除过程中可能很重要。
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