从银水牛果中分离得到的新型可水解单宁——银水牛果素A和B，作为HIV-1逆转录酶抑制剂
New hydrolyzable tannins, shephagenins A and B, from Shepherdia argentea as HIV-1 reverse transcriptase inhibitors.
作者信息
Yoshida T, Ito H, Hatano T, Kurata M, Nakanishi T, Inada A, Murata H, Inatomi Y, Matsuura N, Ono K, Nakane H, Noda M, Lang F A, Murata J
机构信息
Faculty of Pharmaceutical Sciences, Okayama University, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1996 Aug;44(8):1436-9. doi: 10.1248/cpb.44.1436.
Two new hydrolyzable tannins, shephagenins A and B, were isolated along with hippophaenin A and strictinin from the leaf extract of Shepherdia argentea, which showed a remarkable inhibitory activity against human immunodeficiency virus (HIV)-1 reverse transcriptase. Their structures, having a gluconic acid core, have been elucidated on the basis of spectroscopic and chemical methods. The inhibitory effect of the leaf extract on HIV-1 reverse transcriptase was found to be due to tannins, and their activities were stronger than that of (-)-epigallocatechin gallate as a positive control.
从银水牛果的叶提取物中分离出两种新的可水解单宁——银水牛果素A和B，以及沙棘素A和丁香亭，它们对人类免疫缺陷病毒（HIV）-1逆转录酶具有显著的抑制活性。基于光谱和化学方法阐明了它们具有葡萄糖酸核心的结构。发现叶提取物对HIV-1逆转录酶的抑制作用归因于单宁，并且它们的活性比作为阳性对照的（-）-表没食子儿茶素没食子酸酯更强。
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