从小花榄仁叶中提取的两种对HIV-1逆转录酶具有抑制活性的鞣花单宁。

Two ellagitannins from the leaves of Terminalia triflora with inhibitory activity on HIV-1 reverse transcriptase.

作者信息

Martino V, Morales J, Martínez-Irujo J J, Font M, Monge A, Coussio J

机构信息

Cátedra de Farmacognosia, Instituto de Química y Metabolismo del Fármaco (IQUIMEFA) (UBA-CONICET), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, República Argentina.

出版信息

Phytother Res. 2004 Aug;18(8):667-9. doi: 10.1002/ptr.1504.

DOI:10.1002/ptr.1504

PMID:15472920

Abstract

The bioassay- guided fractionation of the aqueous extract of Terminalia triflora leaves afforded punicalin and 2-O-galloylpunicalin, isolated for the first time from this species. These compounds showed inhibitory activity on HIV-1 reverse transcriptase in a dose-dependent manner. Punicalin showed an IC(50) of 0.11 microg/ml (0.14 microM) and 2-O-galloylpunicalin an IC(50) of 0.10 microg/ml (0.11 microM).

摘要

对诃子叶水提取物进行生物测定导向的分级分离，得到了石榴苷和2-O-没食子酰石榴苷，这两种化合物首次从该物种中分离得到。这些化合物对HIV-1逆转录酶表现出剂量依赖性的抑制活性。石榴苷的半数抑制浓度（IC50）为0.11微克/毫升（0.14微摩尔），2-O-没食子酰石榴苷的IC50为0.10微克/毫升（0.11微摩尔）。