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绣球花苷A和B的绝对立体结构，来自山绣球（Hydrangea macrophylla Seringe var. thunbergii Makino）叶片的新型生物活性裂环环烯醚萜苷复合物。

Absolute stereostructures of hydramacrosides A and B, new bioactive secoiridoid glucoside complexes from the leaves of Hydrangea macrophylla Seringe var. thunbergii Makino.

作者信息

Yoshikawa M, Ueda T, Matsuda H, Yamahara J, Murakami N

机构信息

Kyoto Pharmaceutical University, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1994 Aug;42(8):1691-3. doi: 10.1248/cpb.42.1691.

DOI:10.1248/cpb.42.1691
PMID:7525087
Abstract

Two new bioactive secoiridoid glucoside complexes named hydramacrosides A and B were isolated from the leaves of Hydrangea macrophylla SERINGE var. thunbergii MAKINO. The absolute stereostructures of hydramacrosides A and B were elucidated on the basis of chemical and physicochemical evidence which included the application of the 13C NMR glycosylation shift rule of 1, 1'-disaccharides and the modified Mosher's method. Hydramacrosides A and B exhibited inhibitory effect on the histamine release from rat mast cells induced by antigen-antibody reaction.

摘要

从绣球花变种（Hydrangea macrophylla SERINGE var. thunbergii MAKINO）的叶子中分离出两种新的具有生物活性的裂环环烯醚萜苷复合物，命名为绣球大苷A和B。基于化学和物理化学证据，包括应用1,1'-二糖的13C NMR糖基化位移规则和改良的莫舍尔方法，阐明了绣球大苷A和B的绝对立体结构。绣球大苷A和B对由抗原-抗体反应诱导的大鼠肥大细胞组胺释放具有抑制作用。

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