Keenan K P, Buhles W C, Huxsoll D L, Williams R G, Hildebrandt P K
Am J Vet Res. 1977 Jun;38(6):851-6.
Beagle dogs inoculated with the agent of Rocky Mountain spotted fever, Rickettsia rickettsii, developed a clinical syndrome that extended from febrile exanthema to death and appeared to be dose related. Infected dogs were anorectic and lethargic and developed cutaneous lesions characteristic of Rocky Mountain spotted fever, including petechia, ecchymosis, edema, and necrosis. Hematologic changes after inoculation included anemia, leukopenia proceeding to leukocytosis, and thrombocytopenia. Changes in blood chemistry values included increases in serum alkaline phosphatase and cholesterol, and hyponatremia and hypochloremia. The prominent histopathologic change was necrotizing vasculitis. The canine disease is comparable with human Rocky Mountain spotted fever on a clinical, hematologic, biochemical, and pathologic basis, and may provide a model system for this disease in man. The results suggest the dog may be involved in the epidemiology of R rickettsii infections.
接种落基山斑疹热病原体立氏立克次体的比格犬出现了一种临床综合征，从发热性皮疹发展到死亡，且似乎与剂量相关。受感染的犬食欲不振、嗜睡，并出现落基山斑疹热特有的皮肤病变，包括瘀点、瘀斑、水肿和坏死。接种后的血液学变化包括贫血、白细胞减少继而白细胞增多以及血小板减少。血液化学值的变化包括血清碱性磷酸酶和胆固醇升高，以及低钠血症和低氯血症。突出的组织病理学变化是坏死性血管炎。犬类疾病在临床、血液学、生物化学和病理学基础上与人类落基山斑疹热相似，可能为人类这种疾病提供一个模型系统。结果表明犬可能参与立氏立克次体感染的流行病学。
