Sammons L S, Kenyon R H, Burger G T, Pedersen C E, Spertzel R O
Am J Vet Res. 1976 Jun;37(6):725-30.
Forty-seven male Macaca mulatta, 3 to 4 kg weight, were inoculated intravenously or subcutaneously with various doses of yolk sac-grown Rickettsia rickettsii. Thirty-four macaques became febrile and exhibited signs of infection ranging from transient illness with a few days of fever to severe illness with subsequent death. The rash appeared more frequently in the macaques inoculated subcutaneously. Febrile macaques that survived had leukocytosis, with concomitant neutrophilia. Febrile macaques that died had, in addition, marked terminal leukopenia and thrombocytopenia. Packed cell volume of all febrile macaques decreased. In almost all of the febrile macaques, there were increased serum urea nitrogen, glutamic-oxaloacetic transaminase, and lactate dehydrogenase and decreased total serum protein and amylase concentrations. A few febrile macaques had increased bilirubin values and decreased sodium, chloride, phosphorus, and alkaline phosphatase concentrations. Changes did not occur in serum glucose, potassium, calcium, and glutamic-pyruvic transaminase values. The experimental form of Rocky Mountain spotted fever in the macaque provides a subhuman primate model for studying the pathophysiology of this disease.
47只体重为3至4千克的雄性恒河猴，通过静脉注射或皮下注射接种了不同剂量的卵黄囊培养的立氏立克次体。34只猕猴出现发热，并表现出从伴有数天发热的短暂疾病到严重疾病并随后死亡的感染迹象。皮疹在皮下接种的猕猴中出现得更为频繁。存活的发热猕猴有白细胞增多症，并伴有嗜中性粒细胞增多。死亡的发热猕猴除此之外，还出现明显的末期白细胞减少和血小板减少。所有发热猕猴的红细胞压积均下降。几乎所有发热猕猴的血清尿素氮、谷草转氨酶和乳酸脱氢酶都升高，血清总蛋白和淀粉酶浓度降低。少数发热猕猴的胆红素值升高，钠、氯、磷和碱性磷酸酶浓度降低。血清葡萄糖、钾、钙和谷丙转氨酶值未发生变化。猕猴身上的落基山斑疹热实验形式为研究该疾病的病理生理学提供了一个非人灵长类动物模型。
