结节病中真菌补体结合抗体的患病率。

Prevalence of fungal complement-fixing antibodies in sarcoidosis.

作者信息

Johnson J E, DeRemee R A, Kueppers F, Roberts G D

出版信息

Am Rev Respir Dis. 1977 Jul;116(1):145-7. doi: 10.1164/arrd.1977.116.1.145.

DOI:10.1164/arrd.1977.116.1.145

Abstract

The prevalence of fungal complement-fixing antibodies in sera from 58 patients with sarcoidosis was determined and compared to complement-fixing antibody titers in 50 sera from a normal control group and 50 antinuclear antibody-positive sera. Sera from 9 patients with sarcoidosis had complement-fixing antibody titers greater than 1:8 to Histoplasma yeast antigen; serum from one normal control subject had a titer greater than 1:8; and none of the antinuclear antibody-positive sera demonstrated titers greater than 1:8. There were no significant complement-fixing antibody concentrations observed against histoplasmin, blastomycin, and coccidioidin antigens in any serum from the 3 groups studied. The increase in antibody titers to the Histoplasma yeast antigen might have been related to the generalized increase in immunoglobulin concentrations noted in patients with sarcoidosis.

摘要

测定了58例结节病患者血清中真菌补体结合抗体的患病率，并与50例正常对照组血清和50例抗核抗体阳性血清中的补体结合抗体滴度进行了比较。9例结节病患者血清对组织胞浆菌酵母抗原有大于1:8的补体结合抗体滴度；1例正常对照者血清滴度大于1:8；抗核抗体阳性血清中无一例滴度大于1:8。在所研究的3组中，任何一组血清中均未观察到针对组织胞浆菌素、芽生菌素和球孢子菌素抗原的显著补体结合抗体浓度。对组织胞浆菌酵母抗原的抗体滴度升高可能与结节病患者免疫球蛋白浓度的普遍升高有关。