Bauman D S, Smith C D
J Clin Microbiol. 1976 Aug;2(2):77-80.
The immunodiffusion and complement fixation tests for histoplasmosis were compared on 2,090 initial sera from 70 proven cases of histoplasmosis, 177 routine chest hospital patients, and 1,843 coal miners from outside the major endemic area for histoplasmosis. The complement fixation test using histoplasmin as antigen detected antibodies in the sera of 72.8% of the 70 proven cases, while the complement fixation test using yeast antigen detected antibodies in 94.3% of the case sera, and the immunodiffusion test using histoplasmin antigen detected antibodies in 90% of the sera. The tests were also compared for sensitivity, specificity, and ease of performance.
对来自70例经证实的组织胞浆菌病患者的2090份初始血清、177例常规胸部疾病住院患者以及1843名来自组织胞浆菌病主要流行区以外的煤矿工人的血清，进行了组织胞浆菌病免疫扩散试验和补体结合试验的比较。以组织胞浆菌素作为抗原的补体结合试验在70例经证实的病例中，72.8%的血清检测到抗体；而以酵母抗原的补体结合试验在94.3%的病例血清中检测到抗体；以组织胞浆菌素抗原的免疫扩散试验在90%的血清中检测到抗体。还对这些试验的敏感性、特异性及操作简便性进行了比较。
