Bolk J H, Elte J W, Bussemaker J K, Haak A, van der Heide D
Lancet. 1979 Jul 14;2(8133):61-3. doi: 10.1016/s0140-6736(79)90118-1.
Thyroid-stimulating immunoglobulins (TSIs) were measured by radioreceptor assay in serum from 51 patients with a multinodular goitre, divided into four groups according to thyroid function, and in 30 normal people. In 9 patients who were euthyroid and had non-autonomous thyroid function and in 6 patients who were hyperthyroid, TSI index was normal . Of 21 euthyroid patients with autonomous function only 2 had a slightly abnormal TSI index (66 in both, normal greater than or equal to 68). Another series of 15 clinically euthyroid patients also had a normal TSI index. These results suggest that TSIs do not contribute to the pathogenesis of multinodular goitre, as has been suggested by others.
采用放射受体分析法对51例多结节性甲状腺肿患者（根据甲状腺功能分为四组）和30名正常人血清中的促甲状腺素受体抗体（TSIs）进行了检测。在9例甲状腺功能正常且甲状腺功能非自主性的患者以及6例甲状腺功能亢进患者中，TSI指数正常。在21例甲状腺功能正常且具有自主性的患者中，只有2例TSI指数略有异常（两者均为66，正常范围大于或等于68）。另一组15例临床甲状腺功能正常的患者TSI指数也正常。这些结果表明，促甲状腺素受体抗体并不像其他人所认为的那样参与多结节性甲状腺肿的发病机制。
