Nakakoshi T, Kajiyama M, Fujita N, Jong-Hon K, Takeichi N, Miyasaka K
Department of Radiology, Hokkaido University of Medicine, Sapporo, Japan.
Acad Radiol. 1996 Jan;3(1):36-9. doi: 10.1016/S1076-6332(96)80330-8.
To evaluate the effects of intrahepatic copper on magnetic resonance (MR) images, we studied the signal intensity (SI) of T1-weighted images and the T1 relaxation time of Long-Evans Cinnamon (LEC) rats, which have abnormal copper metabolism, and compared them with those of Sprague-Dawley (SD) rats.
We imaged the livers of four LEC rats before they developed hepatitis and four SD rats. The SI ratio of the liver to a phantom of polyvinyl alcohol gel was measured on T1-weighted images, and the T1 relaxation time was obtained from calculated T1 images. Copper concentration was measured by atomic absorption spectrophotometry.
The mean copper concentrations in the liver of LEC rats were approximately 20-fold and statistically higher than in SD rats. There was no significant difference in the SI ratio and the T1 relaxation time between the LEC and SD rats.
Intrahepatic copper does not significantly influence either the SI of T1-weighted MR images or the T1 relaxation time of the rat liver.
为了评估肝内铜对磁共振（MR）图像的影响，我们研究了具有异常铜代谢的长 Evans 肉桂色（LEC）大鼠的 T1 加权图像信号强度（SI）和 T1 弛豫时间，并将其与斯普拉格-道利（SD）大鼠进行比较。
我们对 4 只未发生肝炎的 LEC 大鼠和 4 只 SD 大鼠的肝脏进行成像。在 T1 加权图像上测量肝脏与聚乙烯醇凝胶体模的 SI 比值，并从计算得到的 T1 图像中获取 T1 弛豫时间。通过原子吸收分光光度法测量铜浓度。
LEC 大鼠肝脏中的平均铜浓度约为 SD 大鼠的 20 倍，且具有统计学差异。LEC 大鼠和 SD 大鼠之间的 SI 比值和 T1 弛豫时间无显著差异。
肝内铜对大鼠肝脏 T1 加权 MR 图像的 SI 或 T1 弛豫时间均无显著影响。
