Chelmow D, Baker E R, Jones L
Department of Obstetrics and Gynecology, Tufts University School of Medicine, Boston, Massachusetts, USA.
J Soc Gynecol Investig. 1996 May-Jun;3(3):127-30.
To examine the effect of an intravenous (i.v.) fluid bolus on the amniotic fluid index (AFI) in patients with preterm ruptured membranes.
Nonlaboring patients at 24-37 weeks' gestation with documented ruptured membranes were randomized to either no hydration or to an i.v. fluid bolus with 1 L of normal saline administered over 30 minutes. All patients had a baseline AFI measured. The same blinded examiner repeated the examination 90 minutes later.
Six patients were randomized to the hydration group, seven to the control group. The groups were similar in age, gravidity, parity, time since rupture, gestational age, and baseline AFI. In the hydration group, the AFI increased 5.1 cm (95% confidence interval [CI] 2.9-7.3) after the fluid bolus. In the no-hydration group, the change was 0.6 cm (95% CI-1.1 to 2.2). The difference in the change in AFI between groups was 4.5 cm (95% CI 1.3-7.7) (P = .008).
The AFI is sensitive to maternal hydration in patients with preterm rupture of membranes and can be increased with an i.v. fluid bolus.
探讨静脉推注液体对胎膜早破患者羊水指数（AFI）的影响。
将妊娠24 - 37周、胎膜已破且未临产的患者随机分为两组，一组不进行补液，另一组静脉推注1升生理盐水，30分钟内输完。所有患者均测量基线羊水指数。90分钟后，由同一位不知情的检查者再次进行检查。
6例患者被随机分配到补液组，7例被分配到对照组。两组在年龄、孕次、产次、破膜时间、孕周和基线羊水指数方面相似。补液组在推注液体后羊水指数增加了5.1厘米（95%置信区间[CI] 2.9 - 7.3）。在未补液组，变化为0.6厘米（95% CI -1.1至2.2）。两组羊水指数变化的差异为4.5厘米（95% CI 1.3 - 7.7）（P = .008）。
羊水指数对胎膜早破患者的母体补液敏感，静脉推注液体可使其升高。
