Harrus S, Waner T, Weiss D J, Keysary A, Bark H
Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel.
Vet Immunol Immunopathol. 1996 May;51(1-2):13-20. doi: 10.1016/0165-2427(95)05516-9.
The pattern of appearance of serum antiplatelet antibodies during the acute phase of experimental canine ehrlichiosis (Ehrlichia canis) was investigated in six beagles and correlated with the development of thrombocytopenia. The earliest detection of serum antiplatelet antibodies was made on Day 7 post-inoculation in one dog, on Day 13 in three out of six dogs, and on Day 17 post-inoculation in the remaining two dogs. Thrombocytopenia developed in all infected dogs. The results of this study suggest that antiplatelet antibodies play a role in the destruction of platelets in the acute phase of the disease. It is proposed that E. canis infection in dogs alters the immune system resulting in the overproduction of natural antiplatelet antibodies.
在六只比格犬中研究了实验性犬埃立克体病（犬埃立克体）急性期血清抗血小板抗体的出现模式，并将其与血小板减少症的发展相关联。最早在接种后第7天在一只犬中检测到血清抗血小板抗体，在六只犬中的三只于第13天检测到，其余两只犬在接种后第17天检测到。所有受感染的犬均出现血小板减少症。本研究结果表明，抗血小板抗体在疾病急性期血小板破坏中起作用。有人提出，犬感染犬埃立克体可改变免疫系统，导致天然抗血小板抗体产生过多。
