分枝杆菌对利福平的通透性屏障
Permeability barrier to rifampin in mycobacteria.
作者信息
Hui J, Gordon N, Kajioka R
出版信息
Antimicrob Agents Chemother. 1977 May;11(5):773-9. doi: 10.1128/AAC.11.5.773.
Abstract
A strain of Mycobacterium intracellulare that exhibited natural resistance to rifampin was isolated. The ribonucleic acid polymerase was found to be susceptible to rifampin. Studies with Tween 80 suggested that a permeability barrier against rifampin was present in the intact organism. A type strain of Mycobacterium smegmatis, ATCC 607, considered resistant to rifampin also demonstrated a permeability barrier. The possibility that rifampin resistance in naturally occurring strains of mycobacteria and variable levels of resistance in strains of certain species of this organism are due to permeability barriers is discussed.
摘要
分离出了一株对利福平表现出天然抗性的胞内分枝杆菌。发现其核糖核酸聚合酶对利福平敏感。用吐温80进行的研究表明，完整的菌体中存在针对利福平的通透屏障。耻垢分枝杆菌的标准菌株ATCC 607，被认为对利福平耐药，也表现出通透屏障。本文讨论了分枝杆菌自然菌株中利福平耐药性以及该生物体某些物种菌株中不同水平耐药性是否归因于通透屏障的可能性。
相似文献
1
Permeability barrier to rifampin in mycobacteria.
Antimicrob Agents Chemother. 1977 May;11(5):773-9. doi: 10.1128/AAC.11.5.773.
2
Biochemical study of R-75-1, a new semi-synthetic rifamycin.
J Antibiot (Tokyo). 1981 Jun;34(6):713-8. doi: 10.7164/antibiotics.34.713.
3
Mode of action of rifampin on mycobacteria. II. Biosynthetic studies on the inhibition of ribonucleic acid polymerase of Mycobacterium bovis BCG by rifampin and uptake of rifampin- 14 C by Mycobacterium phlei.
Am Rev Respir Dis. 1973 Jun;107(6):1006-12. doi: 10.1164/arrd.1973.107.6.1006.
4
Mycobacterium smegmatis RNA polymerase: DNA supercoiling, action of rifampicin and mechanism of rifampicin resistance.
Mol Microbiol. 1993 Apr;8(2):277-85. doi: 10.1111/j.1365-2958.1993.tb01572.x.
5
Mechanism of action of rifampin on Mycobacterium smegmatis.
J Bacteriol. 1971 Nov;108(2):737-41. doi: 10.1128/jb.108.2.737-741.1971.
6
Characterization of rifampin-resistance in pathogenic mycobacteria.
Antimicrob Agents Chemother. 1994 Oct;38(10):2380-6. doi: 10.1128/AAC.38.10.2380.
7
Accumulation of rifampicin by Mycobacterium aurum, Mycobacterium smegmatis and Mycobacterium tuberculosis.
J Antimicrob Chemother. 2000 Feb;45(2):159-65. doi: 10.1093/jac/45.2.159.
8
Mechanism of mycobacteriocin and Tween 80 mediated antimycobacterial activity.
J Gen Microbiol. 1984 Dec;130(12):3085-9. doi: 10.1099/00221287-130-12-3085.
9
Rifamycin resistance in mycobacteria.
Res Microbiol. 1996 Jan-Feb;147(1-2):48-52. doi: 10.1016/0923-2508(96)80203-8.
10
On the possibility of cross-resistance between rifampicin and clofazimine in mycobacteria--a laboratory study.
Zentralbl Bakteriol Mikrobiol Hyg A. 1985 Aug;260(1):113-6. doi: 10.1016/s0176-6724(85)80106-1.
引用本文的文献
1
Deep learning-based prediction of chemical accumulation in a pathogenic mycobacterium.
bioRxiv. 2024 Dec 16:2024.12.15.628588. doi: 10.1101/2024.12.15.628588.
2
Reassessment of the genetic basis of natural rifampin resistance in the genus Rickettsia.
Microbiologyopen. 2024 Aug;13(4):e1431. doi: 10.1002/mbo3.1431.
3
The HO inherently released by the mycobacterial minor subpopulation enhances the survival of the major kin subpopulation against rifampicin.
Curr Res Microb Sci. 2022 Jun 18;3:100148. doi: 10.1016/j.crmicr.2022.100148. eCollection 2022.
4
Elevated Levels of Three Reactive Oxygen Species and Fe(II) in the Antibiotic-Surviving Population of Mycobacteria Facilitate Emergence of Genetic Resisters to Antibiotics.
Antimicrob Agents Chemother. 2022 May 17;66(5):e0228521. doi: 10.1128/aac.02285-21. Epub 2022 Apr 18.
5
Computational modeling and bioinformatic analyses of functional mutations in drug target genes in .
Comput Struct Biotechnol J. 2021 Apr 19;19:2423-2446. doi: 10.1016/j.csbj.2021.04.034. eCollection 2021.
6
Cells Surviving in the Continued Presence of Bactericidal Concentrations of Rifampicin Develop Negatively Charged Thickened Capsular Outer Layer That Restricts Permeability to the Antibiotic.
Front Microbiol. 2020 Dec 17;11:554795. doi: 10.3389/fmicb.2020.554795. eCollection 2020.
7
Distinct Bacterial Pathways Influence the Efficacy of Antibiotics against Mycobacterium tuberculosis.
mSystems. 2020 Aug 4;5(4):e00396-20. doi: 10.1128/mSystems.00396-20.
8
Hypoxic Non-replicating Persistent Develops Thickened Outer Layer That Helps in Restricting Rifampicin Entry.
Front Microbiol. 2019 Oct 11;10:2339. doi: 10.3389/fmicb.2019.02339. eCollection 2019.
9
Peptidoglycan in Mycobacteria: chemistry, biology and intervention.
Glycoconj J. 2018 Oct;35(5):421-432. doi: 10.1007/s10719-018-9842-7. Epub 2018 Sep 19.
10
Sensitization of Gram-negative bacteria to rifampin and OAK combinations.
Sci Rep. 2015 Mar 18;5:9216. doi: 10.1038/srep09216.
本文引用的文献
1
Cold stain for acid-fast bacteria.
Can J Public Health. 1950 Jan;41(1):31.
2
The effect of organic acids on mammalian tubercle bacilli.
J Exp Med. 1950 Oct 1;92(4):319-32. doi: 10.1084/jem.92.4.319.
3
Growth characteristics of mycobacteriophages D28 and D29.
Can J Microbiol. 1962 Jun;8:389-99. doi: 10.1139/m62-051.
4
Studies on the metabolism of Mycobacterium tuberculosis. IV. The effect of fatty acids on the growth of M. tuberculosis var. hominis.
J Bacteriol. 1954 Jun;67(6):731-3. doi: 10.1128/jb.67.6.731-733.1954.
5
A rifampicin resistent rna-polymerase from E. coli altered in the beta-subunit.
FEBS Lett. 1969 Oct 21;5(2):104-106. doi: 10.1016/0014-5793(69)80305-4.
6
Inhibition by fifampin of mycobacteriophage D29 replication in its drug-resistant host, Mycobacterium smergmatis ATCC 607.
Am Rev Respir Dis. 1971 May;103(5):618-24. doi: 10.1164/arrd.1971.103.5.618.
7
Rifampin: in vitro effect on atypical mycobacteria.
Am Rev Respir Dis. 1971 Aug;104(2):272-4. doi: 10.1164/arrd.1971.104.2.272.
8
Interaction of Tween 80 detergent with mycobacteria in synthetic medium. I. Effect of Tween 80 on the growth and turbidimetric response of Mycobacterium avium cultures.
Am Rev Respir Dis. 1971 Nov;104(5):717-27. doi: 10.1164/arrd.1971.104.5.717.
9
Relationship between the N function of bacteriophage lambda and host RNA polymerase.
J Mol Biol. 1972 Mar 28;65(2):259-72. doi: 10.1016/0022-2836(72)90281-1.
10
The antimycobacterial activity of rifampin.
Am Rev Respir Dis. 1968 Apr;97(4):713-4. doi: 10.1164/arrd.1968.97.4.713.
Zotero 插件