分枝杆菌对利福平的通透性屏障
Permeability barrier to rifampin in mycobacteria.
作者信息
Hui J, Gordon N, Kajioka R
出版信息
Antimicrob Agents Chemother. 1977 May;11(5):773-9. doi: 10.1128/AAC.11.5.773.
Abstract
A strain of Mycobacterium intracellulare that exhibited natural resistance to rifampin was isolated. The ribonucleic acid polymerase was found to be susceptible to rifampin. Studies with Tween 80 suggested that a permeability barrier against rifampin was present in the intact organism. A type strain of Mycobacterium smegmatis, ATCC 607, considered resistant to rifampin also demonstrated a permeability barrier. The possibility that rifampin resistance in naturally occurring strains of mycobacteria and variable levels of resistance in strains of certain species of this organism are due to permeability barriers is discussed.
摘要
分离出了一株对利福平表现出天然抗性的胞内分枝杆菌。发现其核糖核酸聚合酶对利福平敏感。用吐温80进行的研究表明，完整的菌体中存在针对利福平的通透屏障。耻垢分枝杆菌的标准菌株ATCC 607，被认为对利福平耐药，也表现出通透屏障。本文讨论了分枝杆菌自然菌株中利福平耐药性以及该生物体某些物种菌株中不同水平耐药性是否归因于通透屏障的可能性。
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