Tomioka H, Saito H
J Gen Microbiol. 1984 Dec;130(12):3085-9. doi: 10.1099/00221287-130-12-3085.
Rapidly growing mycobacteria (14 species, 67 strains) showed a highly significant correlation between their susceptibility to smegmatocin (a Tween-hydrolysing esterase of Mycobacterium smegmatis exhibiting antimicrobial activity in the presence of Tween 80) and sensitivity to oleic acid (a hydrolysis product of Tween 80). Polyoxyethylenesorbitan ether, the other product of Tween 80 hydrolysis, also showed some toxic effect on smegmatocin-sensitive mycobacteria. From Mycobacterium diernhoferi ATCC 19340, a representative smegmatocin-sensitive strain, mutant strains with smegmatocin-resistant phenotypes were isolated. These mutants were more resistant to oleic acid than the parent strain, although their oleic acid resistance was somewhat lower than their smegmatocin resistance.
快速生长分枝杆菌（14种，67株）对耻垢菌素（耻垢分枝杆菌的一种吐温水解酯酶，在吐温80存在时具有抗菌活性）的敏感性与对油酸（吐温80的水解产物）的敏感性之间呈现高度显著的相关性。吐温80水解的另一种产物聚氧乙烯山梨糖醇醚对耻垢菌素敏感的分枝杆菌也显示出一定毒性作用。从耻垢菌素敏感的代表性菌株——迪尔恩霍费尔分枝杆菌ATCC 19340中，分离出了具有耻垢菌素抗性表型的突变菌株。这些突变体比亲本菌株对油酸更具抗性，尽管它们对油酸的抗性略低于对耻垢菌素的抗性。
