头孢拉定在脑脊液中的渗透情况及其注入猫脑室的效果。
Cephradine penetration into cerebrospinal fluid and effects of its administration into the cerebral ventricles of cats.
作者信息
Harik S I, Akl K F, Uwaydah M
出版信息
Antimicrob Agents Chemother. 1977 May;11(5):909-11. doi: 10.1128/AAC.11.5.909.
Abstract
In cats that had high, sustained serum concentrations of cephradine, penetration of the drug into the cerebrospinal fluid (CSF) was poor. Serum cephradine levels were, on the average, 100-fold higher than the CSF levels. On the other hand, the direct injection of cephradine into the lateral cerebral ventricles of cats yielded high CSF cephradine concentrations without evidence of central nervous system toxicity.
摘要
在血清头孢拉定浓度持续处于高水平的猫中，该药物进入脑脊液（CSF）的渗透率很低。血清头孢拉定水平平均比脑脊液水平高100倍。另一方面，将头孢拉定直接注射到猫的侧脑室中会使脑脊液中的头孢拉定浓度升高，且无中枢神经系统毒性迹象。
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