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Antimicrob Agents Chemother. 1977 May;11(5):909-11. doi: 10.1128/AAC.11.5.909.
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本文引用的文献

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Penetration of cephalothin and lincomycin into the cerebrospinal fluid.头孢噻吩和林可霉素进入脑脊液的情况。
Am J Med Sci. 1969 Feb;257(2):125-31. doi: 10.1097/00000441-196902000-00006.
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Treatment of pneumococcal meningitis with cephaloridine.用头孢菌素治疗肺炎球菌性脑膜炎。
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Penetration of cephalothin into the spinal fluid.
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Development of meningitis during cephalothin therapy.头孢噻吩治疗期间脑膜炎的发生
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Pharmacokinetics and penetration characteristics of cefazolin into human spinal fluid.头孢唑林在人体脑脊液中的药代动力学及渗透特性
Curr Ther Res Clin Exp. 1976 Jan;19(1):110-20.
6
Cephalothin and cephaloridine therapy for bacterial meningitis.头孢噻吩和头孢噻啶治疗细菌性脑膜炎。
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头孢拉定在脑脊液中的渗透情况及其注入猫脑室的效果。

Cephradine penetration into cerebrospinal fluid and effects of its administration into the cerebral ventricles of cats.

作者信息

Harik S I, Akl K F, Uwaydah M

出版信息

Antimicrob Agents Chemother. 1977 May;11(5):909-11. doi: 10.1128/AAC.11.5.909.

DOI:10.1128/AAC.11.5.909
PMID:879742
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC352095/
Abstract

In cats that had high, sustained serum concentrations of cephradine, penetration of the drug into the cerebrospinal fluid (CSF) was poor. Serum cephradine levels were, on the average, 100-fold higher than the CSF levels. On the other hand, the direct injection of cephradine into the lateral cerebral ventricles of cats yielded high CSF cephradine concentrations without evidence of central nervous system toxicity.

摘要

在血清头孢拉定浓度持续处于高水平的猫中，该药物进入脑脊液（CSF）的渗透率很低。血清头孢拉定水平平均比脑脊液水平高100倍。另一方面，将头孢拉定直接注射到猫的侧脑室中会使脑脊液中的头孢拉定浓度升高，且无中枢神经系统毒性迹象。