Visser L H, van der Meché F G, Meulstee J, Rothbarth P P, Jacobs B C, Schmitz P I, van Doorn P A
Department of Neurology, University Hospital Dijkzigt, Rotterdam, The Netherlands.
Neurology. 1996 Sep;47(3):668-73. doi: 10.1212/wnl.47.3.668.
Guillain-Barré syndrome (GBS) is usually preceded by infections, in particular cytomegalovirus (CMV) and Campylobacter jejuni infection. We studied the clinical and electrophysiologic features of 20 CMV-associated GBS patients and compared the findings with earlier established data of C. jejuni-related GBS patients (n = 43) and of GBS patients without these infections (n = 71). The patients all participated in the Dutch GBS trial in which we compared the effect of intravenous immune globulins and plasma exchange. We demonstrate that CMV-related GBS patients have a different clinical pattern in comparison with the other two GBS groups. They are significantly younger, initially have a severe course indicated by a high frequency of respiratory insufficiency, and often develop cranial nerve involvement and severe sensory loss. This is in contrast to C. jejuni infection, which is associated with motor GBS. Both infections are associated with delayed recovery compared with the GBS patients without these infections.
吉兰-巴雷综合征（GBS）通常在感染后出现，尤其是巨细胞病毒（CMV）和空肠弯曲菌感染。我们研究了20例与CMV相关的GBS患者的临床和电生理特征，并将结果与早期建立的空肠弯曲菌相关GBS患者（n = 43）和无这些感染的GBS患者（n = 71）的数据进行了比较。这些患者均参与了荷兰GBS试验，我们在该试验中比较了静脉注射免疫球蛋白和血浆置换的效果。我们证明，与其他两组GBS患者相比，与CMV相关的GBS患者具有不同的临床模式。他们明显更年轻，最初病情严重，表现为呼吸功能不全的发生率高，并且常出现颅神经受累和严重感觉丧失。这与与运动性GBS相关的空肠弯曲菌感染形成对比。与无这些感染的GBS患者相比，这两种感染均与恢复延迟有关。
