三种研究青霉素G蛋白质相互作用的新方法的评估。
Evaluation of three newer methods for investigating protein interactions of penicillin G.
作者信息
Peterson L R, Gerding D N, Zinneman H H, Moore B M
出版信息
Antimicrob Agents Chemother. 1977 Jun;11(6):993-8. doi: 10.1128/AAC.11.6.993.
Abstract
THE INTERACTION OF PENICILLIN G WITH HUMAN SERUM PROTEINS WAS EVALUATED BY THREE DIFFERENT TECHNIQUES
rate of dialysis, cross-linked dextran exclusion, and ultracentrifugation. The rate-of-dialysis technique demonstrated that penicillin G binding to serum was immediate but incompletely reversible. Cross-linked dextran adsorbed or trapped significant amounts of penicillin G, necessitating correction factors of more than 10%. Ultracentrifugation was found to be the most reliable method for quantitative protein-binding determinations of penicillins.
摘要
采用三种不同技术评估了青霉素G与人血清蛋白的相互作用：透析速率法、交联葡聚糖排阻法和超速离心法。透析速率法表明，青霉素G与血清的结合是即刻发生的，但不完全可逆。交联葡聚糖吸附或截留了大量青霉素G，因此校正因子超过10%。结果发现，超速离心法是测定青霉素与蛋白质定量结合最可靠的方法。
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