Heneine W
Retrovirus Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
J Acquir Immune Defic Syndr Hum Retrovirol. 1996;13 Suppl 1:S236-41. doi: 10.1097/00042560-199600001-00035.
Phylogenetic analysis of long terminal repeat (LTR) sequences from 29 human T-cell lymphotropic virus type II (HTLV-II) strains from endemic and nonendemic populations led to the proposition of three HTLV-IIa phylogroups (A-I, A-II, and A-III) and four HTLV-IIb phylogroups (B-I, B-II, B-III, B-IV). B-I and B-II represented sequences from U.S. and European intravenous drug users, and B-IV included Amerindian sequences from the Guaymi and Wayuu. Interestingly, sequences from an African Pygmy and Seminole and Pueblo Indians and other non-India U.S. samples clustered together in B-III. Similarly, sequences from the Kayapo Indians from Brazil, a Brazilian blood donor, a Cameroonian, and a Ghanaian prostitute clustered together in A-II. Sequences from non-Indian U.S./European samples and a Pueblo Indian formed A-III. A restriction fragment length polymorphism (RFLP) assay was developed to identify rapidly the prevalence of the A and B phylogroups in 246 HTLV-II samples. The RFLP results suggest that A-III and B-II may represent cosmopolitan subtypes because of global distribution in urban areas. In contrast, B-IV and A-II infections were restricted primarily to Central and South America. The phylogenetic data suggest a possible Amerindian origin for B-III, A-II, and A-III infections in non-Indians and an evolution into A and B subtypes that preceded population migrations to the Americas.
对来自地方病流行区和非流行区人群的29株人类嗜T细胞病毒II型（HTLV-II）毒株的长末端重复序列（LTR）进行系统发育分析，结果提出了3个HTLV-IIa系统发育组（A-I、A-II和A-III）和4个HTLV-IIb系统发育组（B-I、B-II、B-III、B-IV）。B-I和B-II代表来自美国和欧洲静脉吸毒者的序列，B-IV包括来自瓜伊米族和瓦尤族的美洲印第安人序列。有趣的是，来自一名非洲俾格米人、塞米诺尔人和普韦布洛印第安人以及其他非印第安美国样本的序列在B-III中聚类在一起。同样，来自巴西卡亚波印第安人、一名巴西献血者、一名喀麦隆人和一名加纳妓女的序列在A-II中聚类在一起。来自非印第安美国/欧洲样本和一名普韦布洛印第安人的序列形成了A-III。开发了一种限制性片段长度多态性（RFLP）检测方法，以快速鉴定246份HTLV-II样本中A和B系统发育组的流行情况。RFLP结果表明，由于在城市地区的全球分布，A-III和B-II可能代表世界性亚型。相比之下，B-IV和A-II感染主要局限于中美洲和南美洲。系统发育数据表明，非印第安人中B-III、A-II和A-III感染可能起源于美洲印第安人，并在人口迁移到美洲之前演变成A和B亚型。
