Labandeira Javier, Pereiro Manuel, Valdés Fernando, Toribio Jaime
Department of Dermatology, Complejo Hospitalario Universitario, Faculty of Medicine, C/. San Francisco s/n, 15782 Santiago de Compostela, Spain.
Dermatol Surg. 2004 Apr;30(4 Pt 1):517-20. doi: 10.1111/j.1524-4725.2004.30167.x.
Controversy exists as to whether treatment of actinic keratoses with intermittent doses of topical 5-fluorouracil is effective in the absence of significant irritation.
To evaluate the efficacy and degree of irritation of 5-fluorouracil as a function of its application frequency.
A total of 85 actinic keratoses in 53 patients were treated, initially with four applications per week for the first week. After this first week, if intolerable irritation arose, patients were instructed to reduce application frequency to two times per week for the rest of the treatment period.
Treatment was completed for 95.4% of the lesions included, with healing of 88.6% of them. The mean time to healing was 7.4 weeks (with four applications weekly) and 10.2 weeks (with two applications). The healing rate was similar in the two groups. Significant correlations (p<0.001) were observed between application frequency and time to healing.
Intermittent 5-fluorouracil treatment is effective without causing significant irritation, but time to healing increases with declining application frequency.
关于外用5-氟尿嘧啶间歇给药治疗光化性角化病在无明显刺激的情况下是否有效存在争议。
评估5-氟尿嘧啶的疗效和刺激程度与其应用频率的关系。
共治疗了53例患者的85处光化性角化病，最初在第一周每周应用4次。在第一周之后，如果出现无法耐受的刺激，患者被指示在治疗期的剩余时间将应用频率降低至每周2次。
纳入的病变中有95.4%完成了治疗，其中88.6%愈合。平均愈合时间为每周应用4次时为7.4周，每周应用2次时为10.2周。两组的愈合率相似。观察到应用频率与愈合时间之间存在显著相关性（p<0.001）。
间歇性5-氟尿嘧啶治疗有效且不会引起明显刺激，但愈合时间会随着应用频率的降低而增加。
