Marinari R, Fleischmajer R, Schragger A H, Rosenthal A L
Arch Dermatol. 1977 Jul;113(7):930-2.
Thirty five patients with psoriasis (plaque type 26, guttate 3, pustular 4, and erythrodermic 2) were treated with oral mycophenolic acid for a period ranging from 52 to 104 weeks. The average follow-up was 89 weeks, and the dose schedule ranged from 2,400 to 7,200 mg daily. Excellent response was noted in 20 patients, good in 13 patients, and poor in 2. The most common clinical side effects were in the gastrointestinal tract, namely, diarrhea, nausea, abdominal cramps, and soft stools. A high incidence of herpes simplex, herpes zoster, and a flu-like syndrome was noted. Laboratory abnormalities consisted of mild blood hemoglobin reduction, one case of leukopenia (3,9000 WBCs per cubic millimeter), two cases with thrombocytopenia and mild elevation of alkaline phosphatase. Mycophenolic acid appears as a promising drug for the treatment of severe psoriasis.
35例银屑病患者（斑块型26例、点滴状3例、脓疱型4例、红皮病型2例）接受口服霉酚酸治疗，疗程为52至104周。平均随访89周，剂量方案为每日2400至7200毫克。20例患者疗效极佳，13例良好，2例较差。最常见的临床副作用发生在胃肠道，即腹泻、恶心、腹部绞痛和软便。观察到单纯疱疹、带状疱疹和流感样综合征的高发病率。实验室异常包括轻度血红蛋白降低、1例白细胞减少（每立方毫米39000个白细胞）、2例血小板减少和碱性磷酸酶轻度升高。霉酚酸似乎是治疗重度银屑病的一种有前景的药物。
