Gasser R, Reisinger E, Sedaj B, Horvarth R, Seinost G, Keplinger A, Wendelin I, Klein W
Department of Internal Medicine, University Graz.
Acta Med Austriaca. 1996;23(3):99-101.
In this pilot trial, 18 patients participated in an investigation in which the combined therapy of co-trimoxazole and roxithromycin in late Lyme borreliosis was tested. The study has been performed as a result of earlier case reports in "The Lancet" where this combination has been used successfully in order to thwart late Lyme disease. The authors show that 76% of the patients recovered completely. In 2 patients, symptoms could be resolved with i.v. penicillin and 2 did not respond to any antibiotic therapy. These results show that oral therapy of co-trimoxazole and roxithromycin in combination provides similar results as i.v. antibiotics in earlier studies.
在这项试点试验中，18名患者参与了一项调查，该调查测试了复方新诺明和罗红霉素联合治疗晚期莱姆病螺旋体病的效果。这项研究是根据《柳叶刀》早期的病例报告进行的，在这些报告中，这种联合用药已成功用于预防晚期莱姆病。作者表明，76%的患者完全康复。2名患者的症状通过静脉注射青霉素得以缓解，2名患者对任何抗生素治疗均无反应。这些结果表明，复方新诺明和罗红霉素联合口服治疗与早期研究中静脉注射抗生素的效果相似。
