Blanco M D, García O, Olmo R, Teijón J M, Katime I
Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad Computense de Madrid, Spain.
J Chromatogr B Biomed Appl. 1996 May 17;680(1-2):243-53. doi: 10.1016/0378-4347(95)00401-7.
The aim of this work was to test the application of copolymeric poly(acrylamide-co-monopropyl itaconate) (A-MPI) hydrogels on the release of 5-fluorouracil (5-FU). The equilibrium degree of swelling in saline solution was 83 +/- 2%. 5-FU, as the sodium salt, was trapped in gels by placing it in the polymerization feed mixture. The diffusion coefficients for both swelling of the gels and the release of 5-FU were determined, in addition to the activation energies for both processes. To determine the applicability of these copolymers, A-MPI (75:25) gel was subcutaneously implanted in rats and the drug plasma concentration was determined by HPLC.
这项工作的目的是测试共聚的聚（丙烯酰胺 - 共 - 单丙基衣康酸酯）（A - MPI）水凝胶在5 - 氟尿嘧啶（5 - FU）释放方面的应用。在盐溶液中的平衡溶胀度为83±2%。5 - FU作为钠盐，通过将其置于聚合进料混合物中而被包封在凝胶中。除了这两个过程的活化能外，还测定了凝胶溶胀和5 - FU释放的扩散系数。为了确定这些共聚物的适用性，将A - MPI（75:25）凝胶皮下植入大鼠体内，并通过高效液相色谱法测定药物血浆浓度。
