Karadağ E, Saraydin D, Cetinkaya S, Güven O
Chemistry Department, Cumhuriyet University, Sivas, Turkey.
Biomaterials. 1996 Jan;17(1):67-70. doi: 10.1016/0142-9612(96)80757-5.
In this in vitro study, the biocompatibility of acrylamide-based hydrogels such as acrylamide/crotonic and acrylamide/itaconic acid, prepared by using gamma-rays, has been investigated against some biochemical parameters of human serum. The swelling kinetics of acrylamide/crotonic and acrylamide/itaconic acid hydrogels are investigated in distilled water and physiological saline solution and some swelling and diffusion parameters have been calculated. For the analysis of biocompatibility, acrylamide/crotonic and acrylamide/itaconic acid hydrogels are incubated in 10 different human sera for 24 h and their biocompatibilities with some biochemical parameters have been investigated. No significant difference in values before and after the test procedures have been found. It is therefore concluded that acrylamide/crotonic and acrylamide/itaconic acid hydrogels are biocompatible.
在这项体外研究中，对通过伽马射线制备的基于丙烯酰胺的水凝胶（如丙烯酰胺/巴豆酸和丙烯酰胺/衣康酸）针对人血清的一些生化参数的生物相容性进行了研究。研究了丙烯酰胺/巴豆酸和丙烯酰胺/衣康酸水凝胶在蒸馏水和生理盐溶液中的溶胀动力学，并计算了一些溶胀和扩散参数。为了分析生物相容性，将丙烯酰胺/巴豆酸和丙烯酰胺/衣康酸水凝胶在10种不同的人血清中孵育24小时，并研究了它们与一些生化参数的生物相容性。在测试程序前后的值中未发现显著差异。因此得出结论，丙烯酰胺/巴豆酸和丙烯酰胺/衣康酸水凝胶具有生物相容性。
