果蝇sina基因的人类同源物在细胞凋亡和肿瘤抑制中的激活作用。
Activation of the human homologue of the Drosophila sina gene in apoptosis and tumor suppression.
作者信息
Nemani M, Linares-Cruz G, Bruzzoni-Giovanelli H, Roperch J P, Tuynder M, Bougueleret L, Cherif D, Medhioub M, Pasturaud P, Alvaro V, der Sarkissan H, Cazes L, Le Paslier D, Le Gall I, Israeli D, Dausset J, Sigaux F, Chumakov I, Oren M, Calvo F, Amson R B, Cohen D, Telerman A
机构信息
Fondation Jean Dausset, Centre d'Etudes du Polymorphisme Humain (CEPH), Paris, France.
出版信息
Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9039-42. doi: 10.1073/pnas.93.17.9039.
Developmentally regulated genes in Drosophila, which are conserved through evolution, are potential candidates for key functions in biological processes such as cell cycle, programmed cell death, and cancer. We report cloning and characterization of the human homologue of the Drosophila seven in absentia gene (HUMSIAH), which codes for a 282 amino acids putative zinc finger protein. HUMSIAH is localized on human chromosome 16q12-q13. This gene is activated during the physiological program of cell death in the intestinal epithelium. Moreover, human cancer-derived cells selected for suppression of their tumorigenic phenotype exhibit constitutively elevated levels of HUMSIAH mRNA. A similar pattern of expression is also displayed by the p21waf1. These results suggest that mammalian seven in absentia gene, which is a target for activation by p53, may play a role in apoptosis and tumor suppression.
果蝇中受发育调控的基因在进化过程中是保守的，它们可能是细胞周期、程序性细胞死亡和癌症等生物过程中关键功能的潜在候选基因。我们报告了果蝇“七缺失”基因（HUMSIAH）的人类同源基因的克隆和特征分析，该基因编码一种含282个氨基酸的假定锌指蛋白。HUMSIAH定位于人类染色体16q12 - q13。该基因在肠上皮细胞死亡的生理过程中被激活。此外，被选择用于抑制其致瘤表型的人类癌细胞系中，HUMSIAH mRNA水平持续升高。p21waf1也呈现出类似的表达模式。这些结果表明，作为p53激活靶点的哺乳动物“七缺失”基因可能在细胞凋亡和肿瘤抑制中发挥作用。
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