Chao C C, Hu S, Peterson P K
Minneapolis Medical Research Foundation, Minnesota, USA.
J Neurovirol. 1996 Aug;2(4):234-9. doi: 10.3109/13550289609146886.
Activated glial cells (microglia and astrocytes) are a hallmark of a variety of neurodegenerative diseases. Recent in vitro studies have suggested that mediators derived from reactive glial cells (eg, cytokines, reactive oxygen intermediates, nitric oxide, glutamate or quinolinic acids, and neurotoxins) contribute to neuronal injury. Several of these mediators have been implicated in the neuropathogenesis of HIV-1. Although the precise role of glial cell-mediated neurotoxicity in viral infections of the central nervous system has not been established, it is hoped that research in this field will yield new therapies for these infections as well as for immune-mediated neurodegenerative diseases.
活化的神经胶质细胞（小胶质细胞和星形胶质细胞）是多种神经退行性疾病的一个标志。最近的体外研究表明，源自反应性神经胶质细胞的介质（如细胞因子、活性氧中间体、一氧化氮、谷氨酸或喹啉酸以及神经毒素）会导致神经元损伤。其中几种介质与HIV-1的神经发病机制有关。尽管神经胶质细胞介导的神经毒性在中枢神经系统病毒感染中的确切作用尚未明确，但希望该领域的研究能为这些感染以及免疫介导的神经退行性疾病带来新的治疗方法。
