Edwards J A, Denis F, Talbot P J
Laboratory of Neuroimmunovirology, Human Health Research Center, INRS-Institut Armand-Frappier, Université du Québec, 531 Boulevard des Prairies, Québec, H7V 1B7, Laval, Canada.
J Neuroimmunol. 2000 Aug 1;108(1-2):73-81. doi: 10.1016/s0165-5728(00)00266-6.
Multiple sclerosis (MS) is an immune-mediated demyelinating disease that could be triggered by a viral infection. Coronaviruses induce an MS-like disease in rodents, are neuroinvasive in humans and can infect primary cultures of human astrocytes and microglia. Infection of the human astrocytic cell line U-373MG by the OC43 strain of human coronavirus caused an upregulation of IL-6, TNF-alpha, and MCP-1 mRNA expression. This virus also modulated the activity of matrix metalloproteinases-2 and -9 and augmented nitric oxide production in both U-373MG cells and the human microglial cell line CHME-5. Thus, a coronaviral infection of glial cells could lead to the production of inflammatory molecules that have been associated with central nervous system pathologies such as MS.
多发性硬化症（MS）是一种免疫介导的脱髓鞘疾病，可能由病毒感染引发。冠状病毒可在啮齿动物中诱发类似MS的疾病，具有人神经侵袭性，且能感染人星形胶质细胞和小胶质细胞的原代培养物。人冠状病毒OC43株感染人星形胶质细胞系U-373MG导致白细胞介素-6、肿瘤坏死因子-α和单核细胞趋化蛋白-1 mRNA表达上调。该病毒还调节基质金属蛋白酶-2和-9的活性，并增加U-373MG细胞和人小胶质细胞系CHME-5中的一氧化氮生成。因此，胶质细胞的冠状病毒感染可能导致产生与MS等中枢神经系统疾病相关的炎症分子。
