Hasegawa T, Kanasugi H, Hidaka M, Yamamoto T, Abe S, Yamaguchi H
Veterinary Teaching Hospital, Faculty of Agriculture, Miyazaki University, Japan.
Int J Immunopharmacol. 1996 Feb;18(2):103-12. doi: 10.1016/0192-0561(96)00001-x.
Dogs injected intravenously for 3 days with cyclophosphamide (CY) at a dose of 10 mg/kg were given 100 mg/kg of Enterococcus faecalis FK-23 preparation (FK-23) perorally for 14 days to confirm the beneficial effects of the latter drug in neutropenic dogs when orally administered. Although FK-23 treatment did not inhibit CY-induced neutropenia, it augmented neutrophil-reconstituting capacity in these dogs. Increases in the myeloid/ erythroid ratio and neutrophilic lineages were found in the bone marrow of FK-23 administered dogs. The oral administration significantly restored the reduced activity of neutrophil phagocytosis and chemiluminescence in dogs treated with CY. These findings indicate that FK-23 administered perorally not only augments neutrophil reconstitution through the activation of bone marrow but also functions in dogs treated with CY. It may thus be a useful supportive agent to reduce the adverse side-effects associated with the administration of chemotherapeutic agents such as CY.
以10毫克/千克的剂量给犬静脉注射环磷酰胺（CY）3天，然后每天口服100毫克/千克的粪肠球菌FK - 23制剂（FK - 23），持续14天，以确认该药物口服给药对中性粒细胞减少犬的有益作用。尽管FK - 23治疗并未抑制CY诱导的中性粒细胞减少，但它增强了这些犬的中性粒细胞重建能力。在给予FK - 23的犬的骨髓中发现髓系/红系比例和嗜中性粒细胞谱系增加。口服给药显著恢复了用CY治疗的犬中降低的中性粒细胞吞噬和化学发光活性。这些发现表明，口服FK - 23不仅通过激活骨髓增强中性粒细胞重建，而且在接受CY治疗的犬中发挥作用。因此，它可能是一种有用的支持性药物，可减少与CY等化疗药物给药相关的不良副作用。
