Kanasugi H, Hasegawa T, Goto Y, Ohtsuka H, Makimura S, Yamamoto T
Faculty of Agriculture, Miyazaki University, Japan.
Int J Immunopharmacol. 1997 Nov-Dec;19(11-12):655-9. doi: 10.1016/s0192-0561(97)00109-4.
Influence of a single administration of heat-killed Enterococcus faecalis FK-23 preparation (FK-23) on non-specific immune responses was evaluated in healthy dogs. The dogs received a single administration of FK-23 at a dose of 100 mg/kg perorally and thereafter a complete blood count (CBC), leukocyte differential count, phagocytic activity of peripheral blood neutrophils and a lymphocyte blast transformation (LBT) test were assessed. Although FK-23 had no effect on the CBC or leukocyte differential count, treatment of the drug caused a 1.4-fold increase in neutrophil phagocytosis compared to FK-23 non-treated healthy dogs. LBT activities of phytohemagglutinin (PHA) and pokeweed mitogen (PWM) were also activated to twice the control levels and that of concanavalin A (Con A) was increased to one and a half times by the FK-23 treatment. Thus, a single administration of FK-23 appears to augment host resistance through stimulation of the non-specific immune responses in vivo.
在健康犬中评估了单次给予热灭活粪肠球菌FK - 23制剂（FK - 23）对非特异性免疫反应的影响。犬口服给予剂量为100mg/kg的单次FK - 23，之后进行全血细胞计数（CBC）、白细胞分类计数、外周血中性粒细胞吞噬活性和淋巴细胞增殖转化（LBT）试验评估。尽管FK - 23对CBC或白细胞分类计数没有影响，但与未用FK - 23处理的健康犬相比，该药物治疗使中性粒细胞吞噬作用增加了1.4倍。经FK - 23处理后，植物血凝素（PHA）和商陆有丝分裂原（PWM）的LBT活性也被激活至对照水平的两倍，刀豆蛋白A（Con A）的LBT活性增加至对照水平的1.5倍。因此，单次给予FK - 23似乎通过刺激体内非特异性免疫反应来增强宿主抵抗力。
