Ohasi K, Satonaka K, Yamamoto T, Yamazaki M, Kimura S, Abe S, Yamaguchi H
Central Research Laboratories, Nichinichi Pharmaceutical Co., Ltd., Mie, Japan.
Yakugaku Zasshi. 1993 May;113(5):396-9. doi: 10.1248/yakushi1947.113.5_396.
The antitumor activity of a preparation of heat-killed cells of Enterococcus faecalis, FK-23. Intraperitoneal injection of the preparation prolonged the lifespan of C3H/He N mice which were intraperitoneally inoculated with MM46 mammary carcinoma. Not only intraperitoneal but also oral administration of the FK-23 preparation inhibited the growth of these carcinomas inoculated intradermally. The tumor-bearing mice produced tumor necrosis factor (TNF) in their sera 2 h after intravenous injection of OK432. This TNF level increased after the mice were fed with food supplemented with the FK-23 preparation. Additionally, the FK-23 preparation inhibited the growth of Meth A fibrosarcoma in cyclophosphamide-treated BALB/c mice.
粪肠球菌热灭活细胞制剂FK-23的抗肿瘤活性。腹腔注射该制剂可延长经腹腔接种MM46乳腺癌的C3H/He N小鼠的寿命。不仅腹腔注射，口服FK-23制剂也能抑制皮内接种的这些癌的生长。荷瘤小鼠在静脉注射OK432后2小时血清中产生肿瘤坏死因子（TNF）。在给小鼠喂食添加了FK-23制剂的食物后，TNF水平升高。此外，FK-23制剂在环磷酰胺处理的BALB/c小鼠中抑制了Meth A纤维肉瘤的生长。
