钙依赖性预电位有助于大鼠结节乳头体神经元的自发活动。
Calcium-dependent prepotentials contribute to spontaneous activity in rat tuberomammillary neurons.
作者信息
Stevens D R, Haas H L
机构信息
Physiologie Institüt II, Heinrich-Heine-Universität, Düsseldorf, Germany.
出版信息
J Physiol. 1996 Jun 15;493 ( Pt 3)(Pt 3):747-54. doi: 10.1113/jphysiol.1996.sp021419.
Abstract
- Intracellular recordings from histaminergic neurons of the tuberomammillary (TM) nucleus reveal subthreshold depolarizing potentials (DPs) which persist in the presence of tetrodotoxin. 2. Block of hyperpolarization-activated current by 1-4 mM Cs+ failed to reduce spontaneous activity or DPs. 3. In the presence of tetrodotoxin DPs are voltage dependent and are depressed by Cd2+ and Co2+. 4. Ba2+ (100 microM) treatment enhances DP amplitude and converts low-amplitude potentials to tetrodotoxin-insensitive action potentials. 5. In the presence of TTX, DPs are reduced by Ni2+. Spontaneous action potentials are also reduced by Ni2+ (100-300 microM). A low-threshold Ca2+ current is present which is sensitive to Ni2+. These results indicate the presence of calcium currents, perhaps of the low-threshold type, which contribute to activation of action potentials in TM neurons.
摘要
- 对结节乳头体（TM）核中组胺能神经元进行的细胞内记录显示，存在阈下去极化电位（DPs），该电位在河豚毒素存在时依然持续。2. 用1 - 4 mM的Cs⁺阻断超极化激活电流未能降低自发活动或DPs。3. 在河豚毒素存在的情况下，DPs是电压依赖性的，并受到Cd²⁺和Co²⁺的抑制。4. 用100 microM的Ba²⁺处理可增强DPs的幅度，并将低幅度电位转变为对河豚毒素不敏感的动作电位。5. 在TTX存在的情况下，DPs被Ni²⁺降低。自发动作电位也被100 - 300 microM的Ni²⁺降低。存在一种对Ni²⁺敏感的低阈值Ca²⁺电流。这些结果表明存在钙电流，可能是低阈值类型的，它有助于TM神经元动作电位的激活。
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