Müller Jochen, Reyes-Haro Daniel, Pivneva Tatjyana, Nolte Christiane, Schaette Roland, Lübke Joachim, Kettenmann Helmut
Zelluläre Neurowissenschaften, Max-Delbrück-Centrum für Molekulare Medizin, Berlin, Germany.
J Gen Physiol. 2009 Aug;134(2):115-27. doi: 10.1085/jgp.200910194.
Glial cell processes are part of the synaptic structure and sense spillover of transmitter, while some glial cells can even receive direct synaptic input. Here, we report that a defined type of glial cell in the medial nucleus of the trapezoid body (MNTB) receives excitatory glutamatergic synaptic input from the calyx of Held (CoH). This giant glutamatergic terminal forms an axosomatic synapse with a single principal neuron located in the MNTB. The NG2 glia, as postsynaptic principal neurons, establish synapse-like structures with the CoH terminal. In contrast to the principal neurons, which are known to receive excitatory as well as inhibitory inputs, the NG2 glia receive mostly, if not exclusively, alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid receptor-mediated evoked and spontaneous synaptic input. Simultaneous recordings from neurons and NG2 glia indicate that they partially receive synchronized spontaneous input. This shows that an NG2(+) glial cell and a postsynaptic neuron share presynaptic terminals.
神经胶质细胞突起是突触结构的一部分，可感知递质的溢出，而一些神经胶质细胞甚至能接受直接的突触输入。在此，我们报告，梯形体内侧核（MNTB）中一种特定类型的神经胶质细胞接受来自Held壶腹（CoH）的兴奋性谷氨酸能突触输入。这个巨大的谷氨酸能终末与位于MNTB的单个主神经元形成轴-体突触。作为突触后主神经元的NG2神经胶质细胞与CoH终末形成类似突触的结构。与已知既接受兴奋性输入也接受抑制性输入的主神经元不同，NG2神经胶质细胞大多（如果不是完全）接受α-氨基-3-羟基-5-甲基-异恶唑-4-丙酸受体介导的诱发和自发突触输入。对神经元和NG2神经胶质细胞的同步记录表明，它们部分接受同步的自发输入。这表明一个NG2(+)神经胶质细胞和一个突触后神经元共享突触前终末。
