大鼠干扰素。IV. 大鼠血清中的唾液蛋白。
Rat interferons. IV. Sialoproteins in rat serum.
作者信息
Mejbaum-Katzenellenbogen W, Wróblewski Z, Kudrewicz-Hubicka Z, Lobodzińska M, Biernacka I, Skurska Z
出版信息
Arch Immunol Ther Exp (Warsz). 1977;25(1):1-6.
Introduction of virus as inductor of interferon into rats caused a decline in serum levels of sialic acid in blood taken at the time of maximum interferon activity. Differences in the acute phase proteins were dependent on the type of virus used for induction. NDV injected intravenously did not lower serum levels of seromucoid, but given together with DMSO markedly depressed the content of this protein in the serum. Stimulation of interferon production by Sindbis virus was accompanied by a significant rise in levels of seromucoid. The same virus given together with DMSO had no effect on protein level, which remained normal, but lowered the content of sialic acid in proteins.
将病毒作为干扰素诱导剂引入大鼠体内，在干扰素活性达到峰值时采集的血液中，血清唾液酸水平下降。急性期蛋白的差异取决于用于诱导的病毒类型。静脉注射新城疫病毒不会降低血清类粘蛋白水平，但与二甲基亚砜一起使用时，会显著降低血清中该蛋白的含量。辛德毕斯病毒刺激干扰素产生时，血清类粘蛋白水平显著升高。该病毒与二甲基亚砜一起使用时，对蛋白质水平没有影响，蛋白质水平保持正常，但会降低蛋白质中唾液酸的含量。
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