Midgard R, Riise T, Kvåle G, Nyland H
Department of Neurology Molde County Hospital, Norway.
Acta Neurol Scand. 1996 May;93(5):307-14. doi: 10.1111/j.1600-0404.1996.tb00001.x.
Continued studies of frequency trends in carefully selected sites around the world can provide clues to the cause of multiple sclerosis (MS).
Based on information from three different, semi-independent sources of information, we have examined the temporal trends in the average annual age-adjusted rates of disability pension incidence, mortality, and incidence of MS from 1966 to 1991 in Møre and Romsdal County, Norway.
The average annual age-adjusted disability pension incidence rates (1966-68 = 3.62/100,000; 1990-91 = 7.33/100,000), the mortality rates (1966-68 = 0.91/100,000; 1990-91 = 1.88/100,000), and the incidence rates (1966-68 = 4.22/100,000; 1990-91 = 5.02/100,000) all showed a statistically significant increase. The difference in the development of MS-specific disability pension prevalence rates in the county compared to the nation is notable.
We consider that the increase in disability pension incidence, mortality, and incidence of MS is of biological significance. Thus three different sources of information corroborate corresponding trends indicating that better case ascertainment and improved diagnostic facilities only partially can explain the reported MS increase in western Norway.
对世界各地精心挑选地点的发病率趋势进行持续研究可为多发性硬化症（MS）的病因提供线索。
基于来自三个不同、半独立信息源的信息，我们研究了1966年至1991年挪威默勒-鲁姆斯达尔郡年龄调整后的残疾抚恤金发病率、死亡率和MS发病率的时间趋势。
年龄调整后的年平均残疾抚恤金发病率（1966 - 68年 = 3.62/100,000；1990 - 91年 = 7.33/100,000）、死亡率（1966 - 68年 = 0.91/100,000；1990 - 91年 = 1.88/100,000）和发病率（1966 - 68年 = 4.22/100,000；1990 - 91年 = 5.02/100,000）均呈现出统计学上的显著增加。该郡与全国相比，MS特异性残疾抚恤金患病率的发展差异显著。
我们认为残疾抚恤金发病率、死亡率和MS发病率的增加具有生物学意义。因此，三个不同的信息源证实了相应的趋势，表明更好的病例确诊和改进的诊断设施只能部分解释挪威西部报告的MS发病率上升情况。
