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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Smith R E, Little P J, Maguire J A, Stein-Oakley A N, Krozowski Z S

Laboratory of Molecular Hypertension, Baker Institute of Medical Research, Prahran, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1996 Jun-Jul;23(6-7):549-51. doi: 10.1111/j.1440-1681.1996.tb02776.x.

The enzyme 11 beta-hydroxysteroid dehydrogenase type II (11 beta HSD2) confers specificity on the non-specific mineralocorticoid receptor by converting cortisol to cortisone. 2. We have examined the localization of this enzyme in the human skin, myocardium and saphenous vein by immunohistochemical techniques. 3. High amounts of 11 beta HSD2 immunoreactivity were found in smooth muscle cells in the arterioles of the skin, heart and saphenous vein. Lower amounts of staining were also found in longitudinal and concentric smooth muscle cells lining the lumen of the saphenous vein.

Ⅱ型11β-羟基类固醇脱氢酶（11βHSD2）通过将皮质醇转化为可的松，赋予非特异性盐皮质激素受体特异性。2. 我们通过免疫组织化学技术检测了该酶在人皮肤、心肌和大隐静脉中的定位。3. 在皮肤、心脏和大隐静脉小动脉的平滑肌细胞中发现了大量的11βHSD2免疫反应性。在大隐静脉管腔内衬的纵行和环形平滑肌细胞中也发现了较低水平的染色。

Smith R E, Little P J, Maguire J A, Stein-Oakley A N, Krozowski Z S

Laboratory of Molecular Hypertension, Baker Institute of Medical Research, Prahran, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1996 Jun-Jul;23(6-7):549-51. doi: 10.1111/j.1440-1681.1996.tb02776.x.

The enzyme 11 beta-hydroxysteroid dehydrogenase type II (11 beta HSD2) confers specificity on the non-specific mineralocorticoid receptor by converting cortisol to cortisone. 2. We have examined the localization of this enzyme in the human skin, myocardium and saphenous vein by immunohistochemical techniques. 3. High amounts of 11 beta HSD2 immunoreactivity were found in smooth muscle cells in the arterioles of the skin, heart and saphenous vein. Lower amounts of staining were also found in longitudinal and concentric smooth muscle cells lining the lumen of the saphenous vein.

Ⅱ型11β-羟基类固醇脱氢酶（11βHSD2）通过将皮质醇转化为可的松，赋予非特异性盐皮质激素受体特异性。2. 我们通过免疫组织化学技术检测了该酶在人皮肤、心肌和大隐静脉中的定位。3. 在皮肤、心脏和大隐静脉小动脉的平滑肌细胞中发现了大量的11βHSD2免疫反应性。在大隐静脉管腔内衬的纵行和环形平滑肌细胞中也发现了较低水平的染色。