Rossen J W, Horzinek M C, Rottier P J
Virology Division of the Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
Trends Microbiol. 1995 Dec;3(12):486-90. doi: 10.1016/s0966-842x(00)89018-6.
Epithelial cells are the first host cells to be infected by incoming c oronaviruses. Recent observations in vitro show that coronaviruses are released from a specific side of these polarized cells, and this polarized release might be important for the spread of the infection in vivo. Mechanisms for the directional sorting of coronaviruses might be similar to those governing the polar release of secretory proteins.
上皮细胞是最早被入侵的冠状病毒感染的宿主细胞。最近的体外观察表明,冠状病毒从这些极化细胞的特定一侧释放,这种极化释放可能对病毒在体内的传播很重要。冠状病毒定向分选的机制可能类似于控制分泌蛋白极性释放的机制。