Robertson N P, Fraser M, Deans J, Clayton D, Walker N, Compston D A
University of Cambridge Neurology unit, Addenbrooke's Hospital, Cambridge, UK.
Brain. 1996 Apr;119 ( Pt 2):449-55. doi: 10.1093/brain/119.2.449.
Familial aggregation is a cardinal epidemiological feature of multiple sclerosis, but few investigators have systematically examined recurrence risks for relatives of affected individuals in the United Kingdom. As part of a cross-sectional study of multiple sclerosis in Cambridgeshire, pedigree details were taken on 674 probands. Sex-specific, crude and age-adjusted recurrence risks were assessed amongst relatives of probands, applying a statistical model based on the observed age at onset of affected individuals and providing risks for clinical counselling. Details on year of birth, present age or age at death, and disease status were available on 11 391 relatives of successive probands. Nineteen percent of patients reported an additionally affected relative; 128 non-proband affected relatives were identified and the highest risk was observed for sisters. There was a systematic reduction in relative risk with genetic distance from the proband and no preferential recurrence for maternal or paternal relatives.
家族聚集性是多发性硬化症的一个主要流行病学特征，但在英国，很少有研究人员系统地研究过患病个体亲属的复发风险。作为剑桥郡多发性硬化症横断面研究的一部分，对674名先证者的家系细节进行了记录。在先证者的亲属中评估了性别特异性、粗复发风险和年龄调整后的复发风险，应用了基于受影响个体观察到的发病年龄的统计模型，并提供临床咨询风险。连续先证者的11391名亲属提供了出生年份、当前年龄或死亡年龄以及疾病状态的详细信息。19%的患者报告有另外一名患病亲属；识别出128名非先证者患病亲属，其中姐妹的风险最高。随着与先证者遗传距离的增加，相对风险有系统性降低，且母系或父系亲属无优先复发情况。
