特发性扩张型心肌病患者及其无症状亲属的细胞因子谱异常。
Abnormal cytokine profiles in patients with idiopathic dilated cardiomyopathy and their asymptomatic relatives.
作者信息
Marriott J B, Goldman J H, Keeling P J, Baig M K, Dalgleish A G, McKenna W J
机构信息
Division of Oncology, Cellular and Molecular Sciences, St George's Hospital Medical School, London.
出版信息
Heart. 1996 Mar;75(3):287-90. doi: 10.1136/hrt.75.3.287.
Abstract
OBJECTIVES
Immunological abnormalities in idiopathic dilated cardiomyopathy (DCM) include an increase in soluble interleukin (IL)-2 receptor, disease specific cardiac autoantibodies, an HLA-DR4 association, and familial aggregation of disease; however, cytokine profiles have not been defined. Serum concentrations of IL-2, IL-4, IL-10, and IL-12 were measured in patients with DCM (WHO criteria), relatives with asymptomatic left ventricular enlargement (LVE), patients with ischaemic heart failure (IHD), and healthy controls.
DESIGN
Serum from 20 individuals from each of the four groups was assayed for cytokine concentrations by a commercial enzyme linked immunosorbent assay.
RESULTS
IL-2 concentrations were abnormally increased in DCM patients and relatives with LVE. Concentrations of IL-10 were increased in DCM patients. Concentrations of IL-4 and IL-12 were not increased in any of the groups.
CONCLUSION
These abnormalities may reflect defective/inappropriate T cell function in patients with DCM and in their relatives with LVE.
摘要
目的
特发性扩张型心肌病（DCM）的免疫异常包括可溶性白细胞介素（IL）-2受体增加、疾病特异性心脏自身抗体、HLA-DR4关联以及疾病的家族聚集性；然而，细胞因子谱尚未明确。对符合世界卫生组织标准的DCM患者、无症状左心室扩大（LVE）的亲属、缺血性心力衰竭（IHD）患者及健康对照者测定血清白细胞介素-2（IL-2）、白细胞介素-4（IL-4）、白细胞介素-10（IL-10）和白细胞介素-12（IL-12）的浓度。
设计
采用商业酶联免疫吸附测定法检测四组中每组20名个体血清中的细胞因子浓度。
结果
DCM患者及LVE亲属的IL-2浓度异常升高。DCM患者的IL-10浓度升高。四组中IL-4和IL-12的浓度均未升高。
结论
这些异常可能反映了DCM患者及其LVE亲属存在缺陷/不适当的T细胞功能。
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