新型隐球菌的两性霉素B耐药菌株，其甾醇生物合成无改变。
Amphotericin B resistant isolates of Cryptococcus neoformans without alteration in sterol biosynthesis.
作者信息
Joseph-Horne T, Loeffler R S, Hollomon D W, Kelly S L
机构信息
Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, UK.
出版信息
J Med Vet Mycol. 1996 Jun-Jul;34(3):223-5.
PMID:8803806
Abstract
Amphotericin B resistant mutants of Cryptococcus neoformans were isolated accumulating mainly ergosterol. Cross-resistance to azole antifungals was not observed. Together with previous data this indicates that at least three categories of amphotericin B resistance can arise: sterol mutants, amphotericin B and azole cross-resistant mutants and amphotericin B resistant mutants with no azole cross-resistance.
摘要
新型隐球菌的两性霉素B耐药突变体被分离出来，主要积累麦角固醇。未观察到对唑类抗真菌药的交叉耐药性。结合先前的数据，这表明至少可产生三类两性霉素B耐药性：固醇突变体、两性霉素B和唑类交叉耐药突变体以及无唑类交叉耐药性的两性霉素B耐药突变体。
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